Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 388782..389548 | Replicon | chromosome |
| Accession | NZ_CP053807 | ||
| Organism | Vibrio cholerae strain SP6G | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A233HKB4 |
| Locus tag | HPY07_RS15320 | Protein ID | WP_000982256.1 |
| Coordinates | 388782..389279 (-) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | HPY07_RS15325 | Protein ID | WP_001915058.1 |
| Coordinates | 389276..389548 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY07_RS15280 | 384001..384417 | + | 417 | WP_114763324.1 | hypothetical protein | - |
| HPY07_RS15285 | 384557..384835 | - | 279 | WP_065818737.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| HPY07_RS15290 | 384832..385116 | - | 285 | WP_000381185.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY07_RS15295 | 385920..386084 | + | 165 | WP_001902694.1 | DUF645 family protein | - |
| HPY07_RS15300 | 386299..386934 | + | 636 | WP_000691786.1 | DUF2807 domain-containing protein | - |
| HPY07_RS15305 | 387090..387500 | + | 411 | WP_000452032.1 | hypothetical protein | - |
| HPY07_RS15310 | 387595..388014 | + | 420 | WP_175234012.1 | GNAT family N-acetyltransferase | - |
| HPY07_RS15315 | 388157..388639 | + | 483 | WP_175242296.1 | GNAT family N-acetyltransferase | - |
| HPY07_RS15320 | 388782..389279 | - | 498 | WP_000982256.1 | GNAT family N-acetyltransferase | Toxin |
| HPY07_RS15325 | 389276..389548 | - | 273 | WP_001915058.1 | DUF1778 domain-containing protein | Antitoxin |
| HPY07_RS15330 | 390167..390348 | + | 182 | Protein_393 | DUF645 family protein | - |
| HPY07_RS15335 | 391234..391413 | + | 180 | WP_175242297.1 | DUF645 family protein | - |
| HPY07_RS15340 | 391620..392189 | + | 570 | WP_053034771.1 | flavodoxin family protein | - |
| HPY07_RS15345 | 392286..392438 | + | 153 | WP_175242422.1 | DUF3709 domain-containing protein | - |
| HPY07_RS15350 | 392459..392692 | + | 234 | WP_076008607.1 | DUF3709 domain-containing protein | - |
| HPY07_RS15355 | 393117..393299 | + | 183 | WP_175242298.1 | DUF645 family protein | - |
| HPY07_RS15360 | 393416..393610 | + | 195 | WP_175242299.1 | DUF3709 domain-containing protein | - |
| HPY07_RS15365 | 393631..393864 | + | 234 | WP_076008607.1 | DUF3709 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 309110..469370 | 160260 | |
| - | inside | Integron | - | - | 309781..469370 | 159589 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18539.23 Da Isoelectric Point: 8.7753
>T157962 WP_000982256.1 NZ_CP053807:c389279-388782 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
>T157962 NZ_CP069522:4358345-4358602 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 9655.16 Da Isoelectric Point: 6.2988
>AT157962 WP_001915058.1 NZ_CP053807:c389548-389276 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT157962 NZ_CP069522:4358614-4359165 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|