157961

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 384557..385116 Replicon chromosome
Accession NZ_CP053807
Organism Vibrio cholerae strain SP6G

Toxin (Protein)


Gene name relE Uniprot ID A0A151JFE6
Locus tag HPY07_RS15285 Protein ID WP_065818737.1
Coordinates 384557..384835 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0N8UHC9
Locus tag HPY07_RS15290 Protein ID WP_000381185.1
Coordinates 384832..385116 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY07_RS15250 379843..380343 + 501 WP_000686370.1 NAD(P)H-dependent oxidoreductase -
HPY07_RS15255 380477..381286 + 810 WP_175242294.1 GIY-YIG nuclease family protein -
HPY07_RS15260 381424..381960 + 537 WP_175242295.1 AAA family ATPase -
HPY07_RS15265 382107..382859 + 753 WP_095474047.1 hypothetical protein -
HPY07_RS15270 383317..383442 + 126 WP_071919811.1 DUF3265 domain-containing protein -
HPY07_RS15275 383706..383807 + 102 Protein_382 DUF645 family protein -
HPY07_RS15280 384001..384417 + 417 WP_114763324.1 hypothetical protein -
HPY07_RS15285 384557..384835 - 279 WP_065818737.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPY07_RS15290 384832..385116 - 285 WP_000381185.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY07_RS15295 385920..386084 + 165 WP_001902694.1 DUF645 family protein -
HPY07_RS15300 386299..386934 + 636 WP_000691786.1 DUF2807 domain-containing protein -
HPY07_RS15305 387090..387500 + 411 WP_000452032.1 hypothetical protein -
HPY07_RS15310 387595..388014 + 420 WP_175234012.1 GNAT family N-acetyltransferase -
HPY07_RS15315 388157..388639 + 483 WP_175242296.1 GNAT family N-acetyltransferase -
HPY07_RS15320 388782..389279 - 498 WP_000982256.1 GNAT family N-acetyltransferase -
HPY07_RS15325 389276..389548 - 273 WP_001915058.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 309110..469370 160260
- inside Integron - - 309781..469370 159589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10896.60 Da        Isoelectric Point: 4.6794

>T157961 WP_065818737.1 NZ_CP053807:c384835-384557 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQRFPND

Download         Length: 279 bp

>T157961 NZ_CP069522:4322469-4322807 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCAAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTAG
TAGCAAAACGCCACGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10887.22 Da        Isoelectric Point: 8.0775

>AT157961 WP_000381185.1 NZ_CP053807:c385116-384832 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT157961 NZ_CP069522:c4322451-4322398 [Escherichia coli]
AATAGGGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JFE6

Antitoxin

Source ID Structure
AlphaFold DB A0A0N8UHC9

References