Detailed information of TA system TA157960

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 364409..364956
• Replicon: chromosome
• Accession: NZ_CP053807
• Organism: Vibrio cholerae strain SP6G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY07_RS15110
• Protein ID: WP_071179849.1
• Coordinates: 364654..364956 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: HPY07_RS15105
• Protein ID: WP_000861987.1
• Coordinates: 364409..364666 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY07_RS15070	359935..360696	+	762	WP_175242286.1	hypothetical protein	-
HPY07_RS15075	360842..361651	+	810	WP_033933189.1	TIR domain-containing protein	-
HPY07_RS15080	362118..362228	+	111	WP_076008721.1	DUF3265 domain-containing protein	-
HPY07_RS15085	362254..362790	+	537	WP_071178897.1	nucleotidyltransferase family protein	-
HPY07_RS15090	362925..363164	-	240	WP_175242287.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY07_RS15095	363183..363425	-	243	WP_000557292.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY07_RS15100	363667..364206	+	540	WP_071186539.1	hypothetical protein	-
HPY07_RS15105	364409..364666	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY07_RS15110	364654..364956	+	303	WP_071179849.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY07_RS15115	365232..365762	+	531	WP_033930568.1	hypothetical protein	-
HPY07_RS15120	366089..366268	+	180	WP_050418640.1	DUF645 family protein	-
HPY07_RS15125	366626..366805	+	180	Protein_352	DUF645 family protein	-
HPY07_RS15130	366922..366993	+	72	Protein_353	acetyltransferase	-
HPY07_RS15135	367087..367563	+	477	WP_175242288.1	hypothetical protein	-
HPY07_RS15140	367717..368850	+	1134	WP_054757467.1	ATP-binding protein	-
HPY07_RS15145	368843..369457	+	615	WP_175242289.1	HNH endonuclease	-
HPY07_RS15150	369454..369564	+	111	WP_123161812.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	309110..469370	160260
	-	inside	Integron	-	-	309781..469370	159589

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11609.53 Da
• Isoelectric Point: 4.8838

>T157960 WP_071179849.1 NZ_CP053807:364654-364956 [Vibrio cholerae]
MVEIILTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKI
SILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T157960 NZ_CP069522:c4314529-4314242 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTAAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT157960 WP_000861987.1 NZ_CP053807:364409-364666 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT157960 NZ_CP069522:c4314255-4313953 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1T4SLM9