Detailed information of TA system TA157959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 362925..363425
• Replicon: chromosome
• Accession: NZ_CP053807
• Organism: Vibrio cholerae strain SP6G

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HPY07_RS15090
• Protein ID: WP_175242287.1
• Coordinates: 362925..363164 (-)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q7DCR7
• Locus tag: HPY07_RS15095
• Protein ID: WP_000557292.1
• Coordinates: 363183..363425 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY07_RS15055	358140..358709	+	570	WP_053034771.1	flavodoxin family protein	-
HPY07_RS15060	358907..359149	+	243	WP_057558139.1	hypothetical protein	-
HPY07_RS15065	359322..359789	+	468	WP_000702485.1	GNAT family N-acetyltransferase	-
HPY07_RS15070	359935..360696	+	762	WP_175242286.1	hypothetical protein	-
HPY07_RS15075	360842..361651	+	810	WP_033933189.1	TIR domain-containing protein	-
HPY07_RS15080	362118..362228	+	111	WP_076008721.1	DUF3265 domain-containing protein	-
HPY07_RS15085	362254..362790	+	537	WP_071178897.1	nucleotidyltransferase family protein	-
HPY07_RS15090	362925..363164	-	240	WP_175242287.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY07_RS15095	363183..363425	-	243	WP_000557292.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY07_RS15100	363667..364206	+	540	WP_071186539.1	hypothetical protein	-
HPY07_RS15105	364409..364666	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY07_RS15110	364654..364956	+	303	WP_071179849.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY07_RS15115	365232..365762	+	531	WP_033930568.1	hypothetical protein	-
HPY07_RS15120	366089..366268	+	180	WP_050418640.1	DUF645 family protein	-
HPY07_RS15125	366626..366805	+	180	Protein_352	DUF645 family protein	-
HPY07_RS15130	366922..366993	+	72	Protein_353	acetyltransferase	-
HPY07_RS15135	367087..367563	+	477	WP_175242288.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	309110..469370	160260
	-	inside	Integron	-	-	309781..469370	159589

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9294.84 Da
• Isoelectric Point: 10.3745

>T157959 WP_175242287.1 NZ_CP053807:c363164-362925 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSVGKHMAYYTKEANFILIVAVLGQSQLPQKHLKQSRFVS

Nucleotide

• Length: 240 bp

>T157959 NZ_CP069522:4190995-4191147 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTATCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.25 Da
• Isoelectric Point: 5.6630

>AT157959 WP_000557292.1 NZ_CP053807:c363425-363183 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT157959 NZ_CP069522:c4190946-4190889 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin

• AlphaFold DB: Q7DCR7