Detailed information of TA system TA157957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2201556..2203381
• Replicon: chromosome
• Accession: NZ_CP053806
• Organism: Vibrio cholerae strain SP6G

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HPY07_RS09900
• Protein ID: WP_175242095.1
• Coordinates: 2201556..2202917 (+)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HPY07_RS09905
• Protein ID: WP_162809321.1
• Coordinates: 2202914..2203381 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY07_RS09870	2197091..2198755	+	1665	WP_113593498.1	DNA repair protein RecN	-
HPY07_RS09875	2198914..2199273	+	360	WP_001160909.1	outer membrane protein assembly factor BamE	-
HPY07_RS09880	2199349..2199654	-	306	WP_153733899.1	RnfH family protein	-
HPY07_RS09885	2199657..2200091	-	435	WP_000815880.1	type II toxin-antitoxin system RatA family toxin	-
HPY07_RS09890	2200275..2200760	+	486	WP_000162689.1	SsrA-binding protein SmpB	-
HPY07_RS09900	2201556..2202917	+	1362	WP_175242095.1	type II toxin-antitoxin system HipA family toxin	Toxin
HPY07_RS09905	2202914..2203381	+	468	WP_162809321.1	helix-turn-helix domain-containing protein	Antitoxin
HPY07_RS09910	2203809..2204387	+	579	WP_175242096.1	class I SAM-dependent methyltransferase	-
HPY07_RS09915	2204391..2207327	+	2937	WP_175242097.1	DEAD/DEAH box helicase family protein	-
HPY07_RS09920	2207398..2208348	+	951	WP_175242098.1	NERD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-383)

Antitoxin

• Cro/C1-type helix-turn-helix domain (80-138)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51245.13 Da
• Isoelectric Point: 4.8500

>T157957 WP_175242095.1 NZ_CP053806:2201556-2202917 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRQYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Nucleotide

• Length: 1362 bp

>T157957 NZ_CP069522:c3920423-3920025 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGAATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17010.45 Da
• Isoelectric Point: 10.7084

>AT157957 WP_162809321.1 NZ_CP053806:2202914-2203381 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKSATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSSDALKSLLMDGEDG

Nucleotide

• Length: 468 bp

>AT157957 NZ_CP069522:c3920719-3920426 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAACTGGTTAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA