Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 585807..586573 Replicon chromosome
Accession NZ_CP053805
Organism Vibrio cholerae strain SL6Y

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag HPY06_RS16300 Protein ID WP_175231609.1
Coordinates 586076..586573 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HPY06_RS16295 Protein ID WP_000246254.1
Coordinates 585807..586079 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY06_RS16260 581182..581298 - 117 WP_080299869.1 DUF3265 domain-containing protein -
HPY06_RS16265 581299..581913 - 615 WP_101411729.1 hypothetical protein -
HPY06_RS16270 582060..582335 - 276 WP_019283461.1 antibiotic biosynthesis monooxygenase -
HPY06_RS16275 582485..583033 - 549 WP_055045003.1 hypothetical protein -
HPY06_RS16280 583033..583938 - 906 WP_055045002.1 DUF4747 family protein -
HPY06_RS16285 584143..584913 - 771 WP_002044830.1 alpha/beta hydrolase -
HPY06_RS16290 585207..585530 - 324 WP_175231607.1 DUF3709 domain-containing protein -
HPY06_RS16295 585807..586079 + 273 WP_000246254.1 DUF1778 domain-containing protein Antitoxin
HPY06_RS16300 586076..586573 + 498 WP_175231609.1 GNAT family N-acetyltransferase Toxin
HPY06_RS16305 586721..587191 - 471 WP_175231611.1 hypothetical protein -
HPY06_RS16310 587389..587559 - 171 WP_032480857.1 DUF645 family protein -
HPY06_RS16315 587923..588105 - 183 WP_095458040.1 DUF645 family protein -
HPY06_RS16320 588420..588641 - 222 Protein_629 DUF645 family protein -
HPY06_RS16325 589617..591410 - 1794 WP_175231882.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 549333..599478 50145
- inside Integron - - 549333..598232 48899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-89)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18555.19 Da        Isoelectric Point: 8.7811

>T157956 WP_175231609.1 NZ_CP053805:586076-586573 [Vibrio cholerae]
MMNTVLLDKDRHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T157956 NZ_CP069522:3684265-3684483 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9685.19 Da        Isoelectric Point: 6.2988

>AT157956 WP_000246254.1 NZ_CP053805:585807-586079 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT157956 NZ_CP069522:3683865-3684239 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References