Detailed information of TA system TA157956

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 585807..586573
• Replicon: chromosome
• Accession: NZ_CP053805
• Organism: Vibrio cholerae strain SL6Y

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HPY06_RS16300
• Protein ID: WP_175231609.1
• Coordinates: 586076..586573 (+)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HPY06_RS16295
• Protein ID: WP_000246254.1
• Coordinates: 585807..586079 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY06_RS16260	581182..581298	-	117	WP_080299869.1	DUF3265 domain-containing protein	-
HPY06_RS16265	581299..581913	-	615	WP_101411729.1	hypothetical protein	-
HPY06_RS16270	582060..582335	-	276	WP_019283461.1	antibiotic biosynthesis monooxygenase	-
HPY06_RS16275	582485..583033	-	549	WP_055045003.1	hypothetical protein	-
HPY06_RS16280	583033..583938	-	906	WP_055045002.1	DUF4747 family protein	-
HPY06_RS16285	584143..584913	-	771	WP_002044830.1	alpha/beta hydrolase	-
HPY06_RS16290	585207..585530	-	324	WP_175231607.1	DUF3709 domain-containing protein	-
HPY06_RS16295	585807..586079	+	273	WP_000246254.1	DUF1778 domain-containing protein	Antitoxin
HPY06_RS16300	586076..586573	+	498	WP_175231609.1	GNAT family N-acetyltransferase	Toxin
HPY06_RS16305	586721..587191	-	471	WP_175231611.1	hypothetical protein	-
HPY06_RS16310	587389..587559	-	171	WP_032480857.1	DUF645 family protein	-
HPY06_RS16315	587923..588105	-	183	WP_095458040.1	DUF645 family protein	-
HPY06_RS16320	588420..588641	-	222	Protein_629	DUF645 family protein	-
HPY06_RS16325	589617..591410	-	1794	WP_175231882.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	549333..599478	50145
	-	inside	Integron	-	-	549333..598232	48899

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-89)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18555.19 Da
• Isoelectric Point: 8.7811

>T157956 WP_175231609.1 NZ_CP053805:586076-586573 [Vibrio cholerae]
MMNTVLLDKDRHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Nucleotide

• Length: 498 bp

>T157956 NZ_CP069522:3684265-3684483 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9685.19 Da
• Isoelectric Point: 6.2988

>AT157956 WP_000246254.1 NZ_CP053805:585807-586079 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Nucleotide

• Length: 273 bp

>AT157956 NZ_CP069522:3683865-3684239 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG