Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-RelB |
| Location | 574415..574955 | Replicon | chromosome |
| Accession | NZ_CP053805 | ||
| Organism | Vibrio cholerae strain SL6Y | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | HPY06_RS16200 | Protein ID | WP_175231601.1 |
| Coordinates | 574686..574955 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KML3 |
| Locus tag | HPY06_RS16195 | Protein ID | WP_001258569.1 |
| Coordinates | 574415..574693 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY06_RS16150 | 569837..570223 | - | 387 | WP_175231593.1 | NUDIX hydrolase | - |
| HPY06_RS16155 | 570487..570723 | + | 237 | WP_000772125.1 | RNA-binding protein | - |
| HPY06_RS16160 | 570910..571299 | - | 390 | WP_000491261.1 | VOC family protein | - |
| HPY06_RS16165 | 571657..571866 | - | 210 | WP_113629352.1 | DUF645 family protein | - |
| HPY06_RS16170 | 572130..572726 | - | 597 | WP_175231595.1 | class I SAM-dependent methyltransferase | - |
| HPY06_RS16175 | 572874..573191 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | - |
| HPY06_RS16180 | 573202..573489 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY06_RS16185 | 573530..573652 | - | 123 | WP_175231597.1 | acetyltransferase | - |
| HPY06_RS16190 | 573725..574129 | - | 405 | WP_175231599.1 | hypothetical protein | - |
| HPY06_RS16195 | 574415..574693 | + | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HPY06_RS16200 | 574686..574955 | + | 270 | WP_175231601.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| HPY06_RS16205 | 574983..575093 | - | 111 | WP_080478885.1 | DUF3265 domain-containing protein | - |
| HPY06_RS16210 | 575090..576628 | - | 1539 | WP_069648548.1 | RNA-directed DNA polymerase | - |
| HPY06_RS16215 | 576768..577268 | - | 501 | WP_071180357.1 | hypothetical protein | - |
| HPY06_RS16220 | 577425..577748 | - | 324 | WP_017047369.1 | ion tolerance protein CutA | - |
| HPY06_RS16225 | 577924..578265 | - | 342 | WP_055030598.1 | hypothetical protein | - |
| HPY06_RS16230 | 578299..578448 | - | 150 | WP_175231603.1 | DUF3265 domain-containing protein | - |
| HPY06_RS16235 | 578414..578869 | - | 456 | WP_017420450.1 | hypothetical protein | - |
| HPY06_RS16240 | 578912..579022 | - | 111 | WP_094143486.1 | DUF3265 domain-containing protein | - |
| HPY06_RS16245 | 579019..579534 | - | 516 | WP_175231605.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 549333..599478 | 50145 | |
| - | inside | Integron | - | - | 549333..598232 | 48899 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10337.01 Da Isoelectric Point: 8.9252
>T157955 WP_175231601.1 NZ_CP053805:574686-574955 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
SIGSHSDLF
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
SIGSHSDLF
Download Length: 270 bp
>T157955 NZ_CP069522:c2961359-2960979 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTTGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTTGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10088.58 Da Isoelectric Point: 6.0728
>AT157955 WP_001258569.1 NZ_CP053805:574415-574693 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
Download Length: 279 bp
>AT157955 NZ_CP069522:c2961780-2961406 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCTTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCTTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|