157954

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-phd/HigB(toxin)
Location 573202..573652 Replicon chromosome
Accession NZ_CP053805
Organism Vibrio cholerae strain SL6Y

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag HPY06_RS16180 Protein ID WP_001162670.1
Coordinates 573202..573489 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HPY06_RS16185 Protein ID WP_175231597.1
Coordinates 573530..573652 (-) Length 41 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY06_RS16135 568243..568740 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
HPY06_RS16140 568901..569224 - 324 WP_017047369.1 ion tolerance protein CutA -
HPY06_RS16145 569382..569666 - 285 WP_043993102.1 antibiotic biosynthesis monooxygenase -
HPY06_RS16150 569837..570223 - 387 WP_175231593.1 NUDIX hydrolase -
HPY06_RS16155 570487..570723 + 237 WP_000772125.1 RNA-binding protein -
HPY06_RS16160 570910..571299 - 390 WP_000491261.1 VOC family protein -
HPY06_RS16165 571657..571866 - 210 WP_113629352.1 DUF645 family protein -
HPY06_RS16170 572130..572726 - 597 WP_175231595.1 class I SAM-dependent methyltransferase -
HPY06_RS16175 572874..573191 - 318 WP_001232701.1 HigA family addiction module antidote protein -
HPY06_RS16180 573202..573489 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY06_RS16185 573530..573652 - 123 WP_175231597.1 acetyltransferase Antitoxin
HPY06_RS16190 573725..574129 - 405 WP_175231599.1 hypothetical protein -
HPY06_RS16195 574415..574693 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HPY06_RS16200 574686..574955 + 270 WP_175231601.1 type II toxin-antitoxin system YafQ family toxin -
HPY06_RS16205 574983..575093 - 111 WP_080478885.1 DUF3265 domain-containing protein -
HPY06_RS16210 575090..576628 - 1539 WP_069648548.1 RNA-directed DNA polymerase -
HPY06_RS16215 576768..577268 - 501 WP_071180357.1 hypothetical protein -
HPY06_RS16220 577425..577748 - 324 WP_017047369.1 ion tolerance protein CutA -
HPY06_RS16225 577924..578265 - 342 WP_055030598.1 hypothetical protein -
HPY06_RS16230 578299..578448 - 150 WP_175231603.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 549333..599478 50145
- inside Integron - - 549333..598232 48899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T157954 WP_001162670.1 NZ_CP053805:c573489-573202 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T157954 NZ_CP069522:2716068-2716175 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 41 a.a.        Molecular weight: 4713.85 Da        Isoelectric Point: 11.4794

>AT157954 WP_175231597.1 NZ_CP053805:c573652-573530 [Vibrio cholerae]
VVMVVVFEFSVMRCQPLRRALCTFLKSFLQIKLVHSVTMR

Download         Length: 123 bp

>AT157954 NZ_CP069522:c2716007-2715952 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F2HI36

Antitoxin

Source ID Structure

References