Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 567974..568740 | Replicon | chromosome |
| Accession | NZ_CP053805 | ||
| Organism | Vibrio cholerae strain SL6Y | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9K2P7 |
| Locus tag | HPY06_RS16135 | Protein ID | WP_000982260.1 |
| Coordinates | 568243..568740 (+) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | HPY06_RS16130 | Protein ID | WP_001915058.1 |
| Coordinates | 567974..568246 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY06_RS16080 | 563131..563409 | + | 279 | WP_000578475.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| HPY06_RS16085 | 563556..564071 | - | 516 | WP_001894921.1 | lipocalin family protein | - |
| HPY06_RS16090 | 564218..564613 | - | 396 | WP_175231590.1 | DUF3465 domain-containing protein | - |
| HPY06_RS16095 | 564930..565160 | - | 231 | WP_175231375.1 | DUF1289 domain-containing protein | - |
| HPY06_RS16100 | 565340..565588 | + | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY06_RS16105 | 565578..565868 | + | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY06_RS16110 | 565995..566291 | - | 297 | Protein_587 | DUF645 family protein | - |
| HPY06_RS16115 | 566605..566847 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| HPY06_RS16120 | 566844..567143 | + | 300 | WP_175231591.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY06_RS16125 | 567261..567743 | - | 483 | WP_174500467.1 | GNAT family N-acetyltransferase | - |
| HPY06_RS16130 | 567974..568246 | + | 273 | WP_001915058.1 | DUF1778 domain-containing protein | Antitoxin |
| HPY06_RS16135 | 568243..568740 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | Toxin |
| HPY06_RS16140 | 568901..569224 | - | 324 | WP_017047369.1 | ion tolerance protein CutA | - |
| HPY06_RS16145 | 569382..569666 | - | 285 | WP_043993102.1 | antibiotic biosynthesis monooxygenase | - |
| HPY06_RS16150 | 569837..570223 | - | 387 | WP_175231593.1 | NUDIX hydrolase | - |
| HPY06_RS16155 | 570487..570723 | + | 237 | WP_000772125.1 | RNA-binding protein | - |
| HPY06_RS16160 | 570910..571299 | - | 390 | WP_000491261.1 | VOC family protein | - |
| HPY06_RS16165 | 571657..571866 | - | 210 | WP_113629352.1 | DUF645 family protein | - |
| HPY06_RS16170 | 572130..572726 | - | 597 | WP_175231595.1 | class I SAM-dependent methyltransferase | - |
| HPY06_RS16175 | 572874..573191 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | - |
| HPY06_RS16180 | 573202..573489 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY06_RS16185 | 573530..573652 | - | 123 | WP_175231597.1 | acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 549333..599478 | 50145 | |
| - | inside | Integron | - | - | 549333..598232 | 48899 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18527.18 Da Isoelectric Point: 8.7753
>T157952 WP_000982260.1 NZ_CP053805:568243-568740 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
>T157952 NZ_CP069522:2161123-2161225 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 91 a.a. Molecular weight: 9655.16 Da Isoelectric Point: 6.2988
>AT157952 WP_001915058.1 NZ_CP053805:567974-568246 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT157952 NZ_CP069522:c2161263-2160995 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|