Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 565340..565868 | Replicon | chromosome |
| Accession | NZ_CP053805 | ||
| Organism | Vibrio cholerae strain SL6Y | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | H9L4R3 |
| Locus tag | HPY06_RS16105 | Protein ID | WP_000221352.1 |
| Coordinates | 565578..565868 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | H9L4T4 |
| Locus tag | HPY06_RS16100 | Protein ID | WP_000213183.1 |
| Coordinates | 565340..565588 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY06_RS16050 | 560461..560776 | + | 316 | Protein_575 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY06_RS16055 | 560934..561197 | - | 264 | WP_000098716.1 | Txe/YoeB family addiction module toxin | - |
| HPY06_RS16060 | 561190..561444 | - | 255 | WP_001223794.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| HPY06_RS16065 | 561670..562065 | - | 396 | WP_175231588.1 | DUF4144 domain-containing protein | - |
| HPY06_RS16070 | 562135..562560 | - | 426 | WP_069217095.1 | hypothetical protein | - |
| HPY06_RS16075 | 562850..563134 | + | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY06_RS16080 | 563131..563409 | + | 279 | WP_000578475.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| HPY06_RS16085 | 563556..564071 | - | 516 | WP_001894921.1 | lipocalin family protein | - |
| HPY06_RS16090 | 564218..564613 | - | 396 | WP_175231590.1 | DUF3465 domain-containing protein | - |
| HPY06_RS16095 | 564930..565160 | - | 231 | WP_175231375.1 | DUF1289 domain-containing protein | - |
| HPY06_RS16100 | 565340..565588 | + | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY06_RS16105 | 565578..565868 | + | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY06_RS16110 | 565995..566291 | - | 297 | Protein_587 | DUF645 family protein | - |
| HPY06_RS16115 | 566605..566847 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| HPY06_RS16120 | 566844..567143 | + | 300 | WP_175231591.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY06_RS16125 | 567261..567743 | - | 483 | WP_174500467.1 | GNAT family N-acetyltransferase | - |
| HPY06_RS16130 | 567974..568246 | + | 273 | WP_001915058.1 | DUF1778 domain-containing protein | - |
| HPY06_RS16135 | 568243..568740 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| HPY06_RS16140 | 568901..569224 | - | 324 | WP_017047369.1 | ion tolerance protein CutA | - |
| HPY06_RS16145 | 569382..569666 | - | 285 | WP_043993102.1 | antibiotic biosynthesis monooxygenase | - |
| HPY06_RS16150 | 569837..570223 | - | 387 | WP_175231593.1 | NUDIX hydrolase | - |
| HPY06_RS16155 | 570487..570723 | + | 237 | WP_000772125.1 | RNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 549333..599478 | 50145 | |
| - | inside | Integron | - | - | 549333..598232 | 48899 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11247.23 Da Isoelectric Point: 10.4678
>T157950 WP_000221352.1 NZ_CP053805:565578-565868 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T157950 NZ_CP069522:1859604-1859858 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8937.28 Da Isoelectric Point: 4.1079
>AT157950 WP_000213183.1 NZ_CP053805:565340-565588 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT157950 NZ_CP069522:1859356-1859607 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | H9L4R3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A366A3W8 |