Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 560934..561444 Replicon chromosome
Accession NZ_CP053805
Organism Vibrio cholerae strain SL6Y

Toxin (Protein)


Gene name relB Uniprot ID A0A0F2IA90
Locus tag HPY06_RS16055 Protein ID WP_000098716.1
Coordinates 560934..561197 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7Y3QZ95
Locus tag HPY06_RS16060 Protein ID WP_001223794.1
Coordinates 561190..561444 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY06_RS16005 555986..556273 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY06_RS16010 556494..557072 - 579 WP_175231584.1 DJ-1/PfpI family protein -
HPY06_RS16015 557268..557450 - 183 WP_033933234.1 DUF645 family protein -
HPY06_RS16020 557745..558200 - 456 WP_055033988.1 hypothetical protein -
HPY06_RS16025 558417..558659 + 243 WP_002044787.1 type II toxin-antitoxin system ParD family antitoxin -
HPY06_RS16030 558656..558955 + 300 WP_000802131.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY06_RS16035 559189..559425 + 237 WP_071179254.1 RNA-binding protein -
HPY06_RS16040 559625..559861 - 237 WP_175231586.1 hypothetical protein -
HPY06_RS16045 560200..560442 + 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY06_RS16050 560461..560776 + 316 Protein_575 type II toxin-antitoxin system RelE/ParE family toxin -
HPY06_RS16055 560934..561197 - 264 WP_000098716.1 Txe/YoeB family addiction module toxin Toxin
HPY06_RS16060 561190..561444 - 255 WP_001223794.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HPY06_RS16065 561670..562065 - 396 WP_175231588.1 DUF4144 domain-containing protein -
HPY06_RS16070 562135..562560 - 426 WP_069217095.1 hypothetical protein -
HPY06_RS16075 562850..563134 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HPY06_RS16080 563131..563409 + 279 WP_000578475.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HPY06_RS16085 563556..564071 - 516 WP_001894921.1 lipocalin family protein -
HPY06_RS16090 564218..564613 - 396 WP_175231590.1 DUF3465 domain-containing protein -
HPY06_RS16095 564930..565160 - 231 WP_175231375.1 DUF1289 domain-containing protein -
HPY06_RS16100 565340..565588 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY06_RS16105 565578..565868 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY06_RS16110 565995..566291 - 297 Protein_587 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 549333..599478 50145
- inside Integron - - 549333..598232 48899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10401.72 Da        Isoelectric Point: 7.9816

>T157948 WP_000098716.1 NZ_CP053805:c561197-560934 [Vibrio cholerae]
MSSRLLSWTDESWDDYLYWQTQDKKTLKRINKIINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDNAITV
ISCRYHY

Download         Length: 264 bp

>T157948 NZ_CP069522:1103131-1103466 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9437.64 Da        Isoelectric Point: 5.0481

>AT157948 WP_001223794.1 NZ_CP053805:c561444-561190 [Vibrio cholerae]
MRIVSFTEARNSLKAVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGKVTQRD
LIDE

Download         Length: 255 bp

>AT157948 NZ_CP069522:1102883-1103131 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F2IA90

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y3QZ95

References