Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 558417..558955 | Replicon | chromosome |
| Accession | NZ_CP053805 | ||
| Organism | Vibrio cholerae strain SL6Y | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A0N8UHD2 |
| Locus tag | HPY06_RS16030 | Protein ID | WP_000802131.1 |
| Coordinates | 558656..558955 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A0Q0JMN6 |
| Locus tag | HPY06_RS16025 | Protein ID | WP_002044787.1 |
| Coordinates | 558417..558659 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY06_RS15985 | 553697..553978 | - | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY06_RS15990 | 554177..554917 | - | 741 | WP_042991272.1 | PhzF family phenazine biosynthesis protein | - |
| HPY06_RS15995 | 555083..555538 | - | 456 | WP_001245329.1 | GNAT family N-acetyltransferase | - |
| HPY06_RS16000 | 555658..555975 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | - |
| HPY06_RS16005 | 555986..556273 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY06_RS16010 | 556494..557072 | - | 579 | WP_175231584.1 | DJ-1/PfpI family protein | - |
| HPY06_RS16015 | 557268..557450 | - | 183 | WP_033933234.1 | DUF645 family protein | - |
| HPY06_RS16020 | 557745..558200 | - | 456 | WP_055033988.1 | hypothetical protein | - |
| HPY06_RS16025 | 558417..558659 | + | 243 | WP_002044787.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| HPY06_RS16030 | 558656..558955 | + | 300 | WP_000802131.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY06_RS16035 | 559189..559425 | + | 237 | WP_071179254.1 | RNA-binding protein | - |
| HPY06_RS16040 | 559625..559861 | - | 237 | WP_175231586.1 | hypothetical protein | - |
| HPY06_RS16045 | 560200..560442 | + | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY06_RS16050 | 560461..560776 | + | 316 | Protein_575 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY06_RS16055 | 560934..561197 | - | 264 | WP_000098716.1 | Txe/YoeB family addiction module toxin | - |
| HPY06_RS16060 | 561190..561444 | - | 255 | WP_001223794.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| HPY06_RS16065 | 561670..562065 | - | 396 | WP_175231588.1 | DUF4144 domain-containing protein | - |
| HPY06_RS16070 | 562135..562560 | - | 426 | WP_069217095.1 | hypothetical protein | - |
| HPY06_RS16075 | 562850..563134 | + | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY06_RS16080 | 563131..563409 | + | 279 | WP_000578475.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 549333..599478 | 50145 | |
| - | inside | Integron | - | - | 549333..598232 | 48899 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11607.26 Da Isoelectric Point: 9.9232
>T157947 WP_000802131.1 NZ_CP053805:558656-558955 [Vibrio cholerae]
MKPFNLTTAAKTDLRDIALFTQRRWGKEQRNIYLKQFDDSFWLLAENPDIGKSCDEIRDGYRKFPQGSHVIFYQQTGSQQ
IRVVRILHKSMDVNPIFGA
MKPFNLTTAAKTDLRDIALFTQRRWGKEQRNIYLKQFDDSFWLLAENPDIGKSCDEIRDGYRKFPQGSHVIFYQQTGSQQ
IRVVRILHKSMDVNPIFGA
Download Length: 300 bp
>T157947 NZ_CP069522:936276-936683 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8979.81 Da Isoelectric Point: 4.1677
>AT157947 WP_002044787.1 NZ_CP053805:558417-558659 [Vibrio cholerae]
MAKNTSITLGEHFDGFITNQIQSGRYGSASEVIRSALRLLENQETKLQTLRQLLVEGEQSGDADYDLDSFINELDSETNR
MAKNTSITLGEHFDGFITNQIQSGRYGSASEVIRSALRLLENQETKLQTLRQLLVEGEQSGDADYDLDSFINELDSETNR
Download Length: 243 bp
>AT157947 NZ_CP069522:936029-936295 [Escherichia coli]
ATGGACATTAATAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAATAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N8UHD2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0JMN6 |