Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 553413..553978 Replicon chromosome
Accession NZ_CP053805
Organism Vibrio cholerae strain SL6Y

Toxin (Protein)


Gene name relE Uniprot ID D7HCW8
Locus tag HPY06_RS15980 Protein ID WP_000869999.1
Coordinates 553413..553700 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag HPY06_RS15985 Protein ID WP_000086649.1
Coordinates 553697..553978 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY06_RS15925 548444..548878 - 435 WP_175231880.1 IS200/IS605 family transposase -
HPY06_RS15930 548865..548992 - 128 Protein_551 DUF645 family protein -
HPY06_RS15935 549333..549809 - 477 WP_001047188.1 GNAT family N-acetyltransferase -
HPY06_RS15940 550006..550188 - 183 WP_175231582.1 DUF645 family protein -
HPY06_RS15945 550461..550862 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
HPY06_RS15950 550862..551032 - 171 WP_001080654.1 hypothetical protein -
HPY06_RS15955 551272..551310 - 39 WP_108244118.1 hypothetical protein -
HPY06_RS15960 551326..551454 - 129 WP_001886422.1 DUF645 family protein -
HPY06_RS15965 551775..552011 - 237 WP_046126177.1 hypothetical protein -
HPY06_RS15970 552014..552397 - 384 Protein_559 PhzF family phenazine biosynthesis protein -
HPY06_RS15975 552894..553217 - 324 WP_080476600.1 DUF3709 domain-containing protein -
HPY06_RS15980 553413..553700 - 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY06_RS15985 553697..553978 - 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY06_RS15990 554177..554917 - 741 WP_042991272.1 PhzF family phenazine biosynthesis protein -
HPY06_RS15995 555083..555538 - 456 WP_001245329.1 GNAT family N-acetyltransferase -
HPY06_RS16000 555658..555975 - 318 WP_001232701.1 HigA family addiction module antidote protein -
HPY06_RS16005 555986..556273 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY06_RS16010 556494..557072 - 579 WP_175231584.1 DJ-1/PfpI family protein -
HPY06_RS16015 557268..557450 - 183 WP_033933234.1 DUF645 family protein -
HPY06_RS16020 557745..558200 - 456 WP_055033988.1 hypothetical protein -
HPY06_RS16025 558417..558659 + 243 WP_002044787.1 type II toxin-antitoxin system ParD family antitoxin -
HPY06_RS16030 558656..558955 + 300 WP_000802131.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 548444..548992 548
- inside Genomic island - - 549333..599478 50145
- inside Integron - - 549333..598232 48899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10997.74 Da        Isoelectric Point: 6.0710

>T157945 WP_000869999.1 NZ_CP053805:c553700-553413 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T157945 NZ_CP069522:c542055-541591 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT157945 WP_000086649.1 NZ_CP053805:c553978-553697 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT157945 NZ_CP069522:c542390-542055 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AEF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References