Detailed information of TA system TA157943

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 396555..397102
• Replicon: chromosome
• Accession: NZ_CP053805
• Organism: Vibrio cholerae strain SL6Y

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY06_RS15175
• Protein ID: WP_175231458.1
• Coordinates: 396800..397102 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY06_RS15170
• Protein ID: WP_175231453.1
• Coordinates: 396555..396812 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY06_RS15135	391728..391838	+	111	Protein_393	DUF3265 domain-containing protein	-
HPY06_RS15140	391922..392635	+	714	WP_175231873.1	Fic family protein	-
HPY06_RS15145	392772..393614	+	843	WP_175231441.1	hypothetical protein	-
HPY06_RS15150	393811..394608	+	798	WP_175231445.1	hypothetical protein	-
HPY06_RS15155	394615..394701	+	87	Protein_397	DUF3265 domain-containing protein	-
HPY06_RS15160	394837..395844	+	1008	WP_175231449.1	hypothetical protein	-
HPY06_RS15165	396150..396303	+	154	Protein_399	DUF645 family protein	-
HPY06_RS15170	396555..396812	+	258	WP_175231453.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY06_RS15175	396800..397102	+	303	WP_175231458.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY06_RS15180	397416..397598	+	183	WP_114763558.1	DUF645 family protein	-
HPY06_RS15185	397749..398111	+	363	WP_032473252.1	DUF4144 domain-containing protein	-
HPY06_RS15190	398272..398889	+	618	WP_158001265.1	SLATT domain-containing protein	-
HPY06_RS15195	399031..399486	+	456	WP_114717223.1	hypothetical protein	-
HPY06_RS15200	399783..399911	+	129	WP_001886422.1	DUF645 family protein	-
HPY06_RS15205	399927..399965	+	39	WP_108244118.1	hypothetical protein	-
HPY06_RS15210	400198..400434	-	237	WP_000772130.1	RNA-binding protein	-
HPY06_RS15215	400727..401059	-	333	WP_095482527.1	SEC-C domain-containing protein	-
HPY06_RS15220	401459..401641	+	183	WP_113629350.1	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	308588..403342	94754
	-	inside	Integron	-	-	309752..402202	92450

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11703.65 Da
• Isoelectric Point: 5.1972

>T157943 WP_175231458.1 NZ_CP053805:396800-397102 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVLYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T157943 NZ_CP069521:8015-8293 [Enterocloster bolteae]
ATGCTTAAGATTGAGTATCAAGGCCAGTTTAAGAAAGATTATAAATTAGCATTAAAACGTGGATGTAATCCTGAACTACT
TACAGAGGTTATATCTATGTTGGCCAATGAGCAAGAACTCCCCGAAAAATATAGGGACCATAACCTTATGAACTCACGGA
GCTATAAAAATGCGAGAGAGTGCCACATACAGCCTGATTGGTTACTCATCTATCAGACAAATAAAGATATCTTAACGCTA
AAATTGTTGCGGACTGGTTCACATAGTGATTTATTTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9695.24 Da
• Isoelectric Point: 8.5040

>AT157943 WP_175231453.1 NZ_CP053805:396555-396812 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHYTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT157943 NZ_CP069521:7747-8022 [Enterocloster bolteae]
ATGTCTGAAAAAAACACAAGTATGAATATCAGAATGAATAAAGATGTGAAACTACAGGCACAGAAAGTTTTTAGTGACCT
TGGAATTGATTTAACCACTGCAGTAAACGTATTTCTGCGCCAATCTATACGTTACCAGGGTTTTCCCTTCGATGTAACCT
TGCGCCAGGAACCAAACGCAACAACTATGGCTGCTATAGAAAATGCGGATAAAGGGATAGACATGCATGGTCCGTTTGAA
TCTGTAGAGGCCCTAATGGAGGACCTTAATGCTTAA