Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 387964..388462 Replicon chromosome
Accession NZ_CP053805
Organism Vibrio cholerae strain SL6Y

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag HPY06_RS15100 Protein ID WP_000589156.1
Coordinates 387964..388230 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag HPY06_RS15105 Protein ID WP_000643598.1
Coordinates 388217..388462 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY06_RS15050 383183..383632 + 450 WP_001026802.1 GyrI-like domain-containing protein -
HPY06_RS15055 383802..384284 + 483 WP_032468092.1 hypothetical protein -
HPY06_RS15060 384281..384784 + 504 WP_001961624.1 ImmA/IrrE family metallo-endopeptidase -
HPY06_RS15065 384897..385250 + 354 WP_108694193.1 DUF4144 domain-containing protein -
HPY06_RS15070 385322..385516 + 195 WP_175231420.1 DUF3709 domain-containing protein -
HPY06_RS15075 385543..385944 + 402 WP_175231425.1 hypothetical protein -
HPY06_RS15080 385923..386051 + 129 WP_175231871.1 DUF3265 domain-containing protein -
HPY06_RS15085 386088..386627 + 540 WP_175231429.1 hydrolase -
HPY06_RS15090 386786..387250 + 465 WP_002033245.1 GNAT family N-acetyltransferase -
HPY06_RS15095 387538..387729 + 192 WP_175231433.1 DUF645 family protein -
HPY06_RS15100 387964..388230 + 267 WP_000589156.1 BrnT family toxin Toxin
HPY06_RS15105 388217..388462 + 246 WP_000643598.1 hypothetical protein Antitoxin
HPY06_RS15110 388762..388944 + 183 WP_057570823.1 DUF645 family protein -
HPY06_RS15115 389145..389663 + 519 WP_055028778.1 GNAT family N-acetyltransferase -
HPY06_RS15120 389903..390139 + 237 WP_000868093.1 DUF645 family protein -
HPY06_RS15125 390342..390806 + 465 WP_002033245.1 GNAT family N-acetyltransferase -
HPY06_RS15130 390951..391718 + 768 WP_175231437.1 hypothetical protein -
HPY06_RS15135 391728..391838 + 111 Protein_393 DUF3265 domain-containing protein -
HPY06_RS15140 391922..392635 + 714 WP_175231873.1 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 308588..403342 94754
- inside Integron - - 309752..402202 92450


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T157942 WP_000589156.1 NZ_CP053805:387964-388230 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T157942 NZ_CP069520:c3192475-3192185 [Enterocloster bolteae]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAGGACTACAAACGAGCCATCAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGTCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTATCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT157942 WP_000643598.1 NZ_CP053805:388217-388462 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT157942 NZ_CP069520:c3192750-3192472 [Enterocloster bolteae]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACGGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTATTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References