Detailed information of TA system TA157938

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 314400..314950
• Replicon: chromosome
• Accession: NZ_CP053805
• Organism: Vibrio cholerae strain SL6Y

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HPY06_RS14470
• Protein ID: WP_095474019.1
• Coordinates: 314400..314711 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P58093
• Locus tag: HPY06_RS14475
• Protein ID: WP_001107719.1
• Coordinates: 314708..314950 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY06_RS14440	309752..310714	-	963	WP_175231319.1	integron integrase IntIA	-
HPY06_RS14445	311116..311269	+	154	Protein_255	DUF645 family protein	-
HPY06_RS14450	311470..311880	+	411	WP_175231321.1	hypothetical protein	-
HPY06_RS14455	311910..312869	-	960	WP_175231324.1	IS30 family transposase	-
HPY06_RS14460	313115..313705	+	591	WP_175231326.1	hypothetical protein	-
HPY06_RS14465	313847..314281	+	435	WP_059261346.1	hypothetical protein	-
HPY06_RS14470	314400..314711	-	312	WP_095474019.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY06_RS14475	314708..314950	-	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HPY06_RS14480	315166..315921	+	756	WP_175231329.1	hypothetical protein	-
HPY06_RS14485	316133..316846	+	714	WP_000123659.1	Fic family protein	-
HPY06_RS14490	316963..317262	-	300	WP_000802134.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY06_RS14495	317259..317501	-	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	-
HPY06_RS14500	317740..318810	+	1071	WP_094132855.1	hypothetical protein	-
HPY06_RS14505	318804..318917	+	114	Protein_267	DUF3265 domain-containing protein	-
HPY06_RS14510	319104..319319	+	216	WP_154139263.1	DUF645 family protein	-
HPY06_RS14515	319496..319909	+	414	WP_095475342.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	308588..403342	94754
	-	inside	Integron	-	-	309752..402202	92450

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12056.85 Da
• Isoelectric Point: 10.1772

>T157938 WP_095474019.1 NZ_CP053805:c314711-314400 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGRITPA

Nucleotide

• Length: 312 bp

>T157938 NZ_CP069517:4670395-4670604 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8964.84 Da
• Isoelectric Point: 4.1677

>AT157938 WP_001107719.1 NZ_CP053805:c314950-314708 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Nucleotide

• Length: 243 bp

>AT157938 NZ_CP069517:4670601-4670903 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGTGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A151JFU4