Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 314400..314950 Replicon chromosome
Accession NZ_CP053805
Organism Vibrio cholerae strain SL6Y

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HPY06_RS14470 Protein ID WP_095474019.1
Coordinates 314400..314711 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag HPY06_RS14475 Protein ID WP_001107719.1
Coordinates 314708..314950 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY06_RS14440 309752..310714 - 963 WP_175231319.1 integron integrase IntIA -
HPY06_RS14445 311116..311269 + 154 Protein_255 DUF645 family protein -
HPY06_RS14450 311470..311880 + 411 WP_175231321.1 hypothetical protein -
HPY06_RS14455 311910..312869 - 960 WP_175231324.1 IS30 family transposase -
HPY06_RS14460 313115..313705 + 591 WP_175231326.1 hypothetical protein -
HPY06_RS14465 313847..314281 + 435 WP_059261346.1 hypothetical protein -
HPY06_RS14470 314400..314711 - 312 WP_095474019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY06_RS14475 314708..314950 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HPY06_RS14480 315166..315921 + 756 WP_175231329.1 hypothetical protein -
HPY06_RS14485 316133..316846 + 714 WP_000123659.1 Fic family protein -
HPY06_RS14490 316963..317262 - 300 WP_000802134.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY06_RS14495 317259..317501 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin -
HPY06_RS14500 317740..318810 + 1071 WP_094132855.1 hypothetical protein -
HPY06_RS14505 318804..318917 + 114 Protein_267 DUF3265 domain-containing protein -
HPY06_RS14510 319104..319319 + 216 WP_154139263.1 DUF645 family protein -
HPY06_RS14515 319496..319909 + 414 WP_095475342.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 308588..403342 94754
- inside Integron - - 309752..402202 92450


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12056.85 Da        Isoelectric Point: 10.1772

>T157938 WP_095474019.1 NZ_CP053805:c314711-314400 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGRITPA

Download         Length: 312 bp

>T157938 NZ_CP069517:4670395-4670604 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT157938 WP_001107719.1 NZ_CP053805:c314950-314708 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT157938 NZ_CP069517:4670601-4670903 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGTGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References