Detailed information of TA system TA157937

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2159420..2161245
• Replicon: chromosome
• Accession: NZ_CP053804
• Organism: Vibrio cholerae strain SL6Y

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HPY06_RS09725
• Protein ID: WP_000391997.1
• Coordinates: 2159420..2160781 (+)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HPY06_RS09730
• Protein ID: WP_000804848.1
• Coordinates: 2160778..2161245 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY06_RS09695	2154953..2156617	+	1665	WP_175230664.1	DNA repair protein RecN	-
HPY06_RS09700	2156776..2157135	+	360	WP_001160907.1	outer membrane protein assembly factor BamE	-
HPY06_RS09705	2157213..2157518	-	306	WP_175230667.1	RnfH family protein	-
HPY06_RS09710	2157521..2157955	-	435	WP_000815880.1	type II toxin-antitoxin system RatA family toxin	-
HPY06_RS09715	2158139..2158624	+	486	WP_000162689.1	SsrA-binding protein SmpB	-
HPY06_RS09725	2159420..2160781	+	1362	WP_000391997.1	type II toxin-antitoxin system HipA family toxin	Toxin
HPY06_RS09730	2160778..2161245	+	468	WP_000804848.1	helix-turn-helix domain-containing protein	Antitoxin
HPY06_RS09735	2161525..2163855	-	2331	WP_175230669.1	DUF2357 domain-containing protein	-
HPY06_RS09740	2163882..2165615	-	1734	WP_175230672.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-383)

Antitoxin

• Cro/C1-type helix-turn-helix domain (80-138)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51275.15 Da
• Isoelectric Point: 4.9109

>T157937 WP_000391997.1 NZ_CP053804:2159420-2160781 [Vibrio cholerae]
VEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Nucleotide

• Length: 1362 bp

>T157937 NZ_CP069517:c4662578-4662240 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAACCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAG
TAACAAAACGCCACGCTAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17048.54 Da
• Isoelectric Point: 10.7084

>AT157937 WP_000804848.1 NZ_CP053804:2160778-2161245 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKSATHSSKEQTPLDTPTRSKASKNVKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Nucleotide

• Length: 468 bp

>AT157937 NZ_CP069517:4662573-4662649 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT