Detailed information of TA system TA157933

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 495120..495667
• Replicon: chromosome
• Accession: NZ_CP053803
• Organism: Vibrio cholerae strain L6G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D7HHP0
• Locus tag: HPY16_RS15730
• Protein ID: WP_000229320.1
• Coordinates: 495365..495667 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: HPY16_RS15725
• Protein ID: WP_000861987.1
• Coordinates: 495120..495377 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY16_RS15695	490420..491412	+	993	WP_170887264.1	hypothetical protein	-
HPY16_RS15700	491546..492028	+	483	WP_000422942.1	GNAT family N-acetyltransferase	-
HPY16_RS15705	492182..492622	+	441	WP_175248457.1	DUF1311 domain-containing protein	-
HPY16_RS15710	493232..493768	+	537	WP_019281268.1	GNAT family N-acetyltransferase	-
HPY16_RS15715	493935..494393	+	459	WP_134987534.1	hypothetical protein	-
HPY16_RS15720	494689..494871	+	183	WP_000947519.1	DUF645 family protein	-
HPY16_RS15725	495120..495377	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY16_RS15730	495365..495667	+	303	WP_000229320.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY16_RS15735	495832..496170	+	339	WP_046127316.1	hypothetical protein	-
HPY16_RS15740	496326..496667	+	342	WP_000452087.1	hypothetical protein	-
HPY16_RS15745	496807..497553	+	747	WP_033929253.1	HNH endonuclease	-
HPY16_RS15750	497805..498218	+	414	WP_000049417.1	VOC family protein	-
HPY16_RS15755	498384..499388	+	1005	WP_175248458.1	LD-carboxypeptidase	-
HPY16_RS15760	499526..499942	+	417	WP_146779584.1	hypothetical protein	-
HPY16_RS15765	500085..500603	+	519	WP_042988833.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-7	-	309435..510278	200843
	-	inside	Integron	-	-	310548..509407	198859

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11682.58 Da
• Isoelectric Point: 4.8838

>T157933 WP_000229320.1 NZ_CP053803:495365-495667 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKI
SILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T157933 NZ_CP069517:3736513-3736890 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCTGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGGCATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT157933 WP_000861987.1 NZ_CP053803:495120-495377 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT157933 NZ_CP069517:3736055-3736423 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGATGCCGATACCCTGGGCAGTTG
TGGTTACGTGTATATCGCCATTTATCCGACACCCGGAACGAAAACATAA

Structures

Toxin

• AlphaFold DB: D7HHP0

Antitoxin

• AlphaFold DB: A0A1T4SLM9