157932

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 489772..490267 Replicon chromosome
Accession NZ_CP053803
Organism Vibrio cholerae strain L6G

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag HPY16_RS15685 Protein ID WP_000589156.1
Coordinates 489772..490038 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HPY16_RS15690 Protein ID WP_033933251.1
Coordinates 490025..490267 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY16_RS15640 484935..485237 + 303 WP_033930520.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY16_RS15645 485398..485886 + 489 WP_033933186.1 hypothetical protein -
HPY16_RS15650 486236..486331 + 96 WP_001907607.1 DUF645 family protein -
HPY16_RS15655 486538..486963 + 426 WP_061051384.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
HPY16_RS15660 487247..487522 + 276 WP_175248456.1 hypothetical protein -
HPY16_RS15665 487528..488013 + 486 WP_113629421.1 hypothetical protein -
HPY16_RS15670 488203..488700 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
HPY16_RS15675 488697..488969 - 273 WP_000246254.1 DUF1778 domain-containing protein -
HPY16_RS15680 489386..489538 + 153 WP_175248612.1 DUF645 family protein -
HPY16_RS15685 489772..490038 + 267 WP_000589156.1 BrnT family toxin Toxin
HPY16_RS15690 490025..490267 + 243 WP_033933251.1 hypothetical protein Antitoxin
HPY16_RS15695 490420..491412 + 993 WP_170887264.1 hypothetical protein -
HPY16_RS15700 491546..492028 + 483 WP_000422942.1 GNAT family N-acetyltransferase -
HPY16_RS15705 492182..492622 + 441 WP_175248457.1 DUF1311 domain-containing protein -
HPY16_RS15710 493232..493768 + 537 WP_019281268.1 GNAT family N-acetyltransferase -
HPY16_RS15715 493935..494393 + 459 WP_134987534.1 hypothetical protein -
HPY16_RS15720 494689..494871 + 183 WP_000947519.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCARB-7 - 309435..510278 200843
- inside Integron - - 310548..509407 198859


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T157932 WP_000589156.1 NZ_CP053803:489772-490038 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T157932 NZ_CP069517:c3516538-3516431 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9363.68 Da        Isoelectric Point: 6.8806

>AT157932 WP_033933251.1 NZ_CP053803:490025-490267 [Vibrio cholerae]
MKAHEFDAKFESDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSVR

Download         Length: 243 bp

>AT157932 NZ_CP069517:3516595-3516652 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure

References