Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 484690..485237 | Replicon | chromosome |
| Accession | NZ_CP053803 | ||
| Organism | Vibrio cholerae strain L6G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | HPY16_RS15640 | Protein ID | WP_033930520.1 |
| Coordinates | 484935..485237 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | HPY16_RS15635 | Protein ID | WP_000861987.1 |
| Coordinates | 484690..484947 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY16_RS15600 | 480223..480687 | + | 465 | WP_032473198.1 | ASCH domain-containing protein | - |
| HPY16_RS15605 | 480833..481753 | + | 921 | WP_134987527.1 | hypothetical protein | - |
| HPY16_RS15610 | 481750..482367 | + | 618 | WP_175248455.1 | hypothetical protein | - |
| HPY16_RS15615 | 482340..482474 | + | 135 | WP_175248611.1 | DUF3265 domain-containing protein | - |
| HPY16_RS15620 | 482511..483050 | + | 540 | WP_000884560.1 | hydrolase | - |
| HPY16_RS15625 | 483213..483992 | + | 780 | WP_001887508.1 | NYN domain-containing protein | - |
| HPY16_RS15630 | 484323..484440 | + | 118 | Protein_572 | DUF645 family protein | - |
| HPY16_RS15635 | 484690..484947 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY16_RS15640 | 484935..485237 | + | 303 | WP_033930520.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY16_RS15645 | 485398..485886 | + | 489 | WP_033933186.1 | hypothetical protein | - |
| HPY16_RS15650 | 486236..486331 | + | 96 | WP_001907607.1 | DUF645 family protein | - |
| HPY16_RS15655 | 486538..486963 | + | 426 | WP_061051384.1 | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | - |
| HPY16_RS15660 | 487247..487522 | + | 276 | WP_175248456.1 | hypothetical protein | - |
| HPY16_RS15665 | 487528..488013 | + | 486 | WP_113629421.1 | hypothetical protein | - |
| HPY16_RS15670 | 488203..488700 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| HPY16_RS15675 | 488697..488969 | - | 273 | WP_000246254.1 | DUF1778 domain-containing protein | - |
| HPY16_RS15680 | 489386..489538 | + | 153 | WP_175248612.1 | DUF645 family protein | - |
| HPY16_RS15685 | 489772..490038 | + | 267 | WP_000589156.1 | BrnT family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | blaCARB-7 | - | 309435..510278 | 200843 | |
| - | inside | Integron | - | - | 310548..509407 | 198859 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11695.54 Da Isoelectric Point: 4.8838
>T157930 WP_033930520.1 NZ_CP053803:484935-485237 [Vibrio cholerae]
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T157930 NZ_CP069517:c2433927-2433616 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT157930 WP_000861987.1 NZ_CP053803:484690-484947 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT157930 NZ_CP069517:c2433619-2433200 [Escherichia coli]
ATGACTGCTAATGCTGTACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGACGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
ATGACTGCTAATGCTGTACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGACGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|