Detailed information of TA system TA157929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 438968..439506
• Replicon: chromosome
• Accession: NZ_CP053803
• Organism: Vibrio cholerae strain L6G

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HPY16_RS15205
• Protein ID: WP_000802134.1
• Coordinates: 438968..439267 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A271VK51
• Locus tag: HPY16_RS15210
• Protein ID: WP_001107720.1
• Coordinates: 439264..439506 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY16_RS15175	434678..436057	+	1380	WP_095476768.1	hypothetical protein	-
HPY16_RS15180	436064..436189	+	126	WP_095476771.1	DUF3265 domain-containing protein	-
HPY16_RS15185	436239..436664	+	426	WP_000620001.1	N-acetyltransferase	-
HPY16_RS15190	436959..437141	+	183	WP_001933694.1	DUF645 family protein	-
HPY16_RS15195	437335..437760	+	426	WP_142732885.1	GNAT family N-acetyltransferase	-
HPY16_RS15200	437915..438310	+	396	WP_000870869.1	DUF3465 domain-containing protein	-
HPY16_RS15205	438968..439267	-	300	WP_000802134.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY16_RS15210	439264..439506	-	243	WP_001107720.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HPY16_RS15215	439731..440474	+	744	WP_175248445.1	toll/interleukin-1 receptor domain-containing protein	-
HPY16_RS15220	440825..440920	+	96	WP_001907607.1	DUF645 family protein	-
HPY16_RS15225	441143..441382	+	240	WP_114967328.1	hypothetical protein	-
HPY16_RS15230	441632..441733	+	102	WP_001921603.1	hypothetical protein	-
HPY16_RS15235	441723..442109	+	387	WP_175248446.1	VOC family protein	-
HPY16_RS15240	442384..442584	+	201	WP_114967371.1	DUF645 family protein	-
HPY16_RS15245	442762..442974	+	213	WP_069573293.1	hypothetical protein	-
HPY16_RS15250	443120..443230	+	111	WP_080308943.1	DUF3265 domain-containing protein	-
HPY16_RS15255	443269..443655	+	387	WP_134987516.1	NUDIX hydrolase	-
HPY16_RS15260	443793..444134	+	342	WP_134987691.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-7	-	309435..510278	200843
	-	inside	Integron	-	-	310548..509407	198859

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11601.34 Da
• Isoelectric Point: 9.9232

>T157929 WP_000802134.1 NZ_CP053803:c439267-438968 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA

Nucleotide

• Length: 300 bp

>T157929 NZ_CP069517:c1743093-1742842 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8950.82 Da
• Isoelectric Point: 4.1677

>AT157929 WP_001107720.1 NZ_CP053803:c439506-439264 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR

Nucleotide

• Length: 243 bp

>AT157929 NZ_CP069517:c1742845-1742591 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGATCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A271VK51