Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 409319..409897 | Replicon | chromosome |
| Accession | NZ_CP053803 | ||
| Organism | Vibrio cholerae strain L6G | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | HPY16_RS14970 | Protein ID | WP_046126185.1 |
| Coordinates | 409319..409636 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A366AI09 |
| Locus tag | HPY16_RS14975 | Protein ID | WP_000557291.1 |
| Coordinates | 409655..409897 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY16_RS14905 | 404386..404919 | + | 534 | WP_175248331.1 | hypothetical protein | - |
| HPY16_RS14910 | 405086..405376 | - | 291 | WP_154171015.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY16_RS14915 | 405366..405614 | - | 249 | WP_000126952.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY16_RS14920 | 405671..405781 | + | 111 | WP_099609988.1 | DUF3265 domain-containing protein | - |
| HPY16_RS14925 | 405958..406176 | + | 219 | WP_044128180.1 | DUF3709 domain-containing protein | - |
| HPY16_RS14930 | 406454..406969 | + | 516 | WP_175248430.1 | hypothetical protein | - |
| HPY16_RS14935 | 406971..407087 | + | 117 | WP_081981487.1 | DUF3265 domain-containing protein | - |
| HPY16_RS14940 | 407273..407455 | + | 183 | WP_000923156.1 | DUF645 family protein | - |
| HPY16_RS14945 | 407571..407684 | + | 114 | WP_175248431.1 | acetyltransferase | - |
| HPY16_RS14950 | 407633..407914 | + | 282 | WP_175248432.1 | DUF1289 domain-containing protein | - |
| HPY16_RS14955 | 408182..408571 | + | 390 | WP_114709500.1 | hypothetical protein | - |
| HPY16_RS14960 | 408628..408750 | + | 123 | WP_175248433.1 | acetyltransferase | - |
| HPY16_RS14965 | 408747..409079 | - | 333 | WP_095482527.1 | SEC-C domain-containing protein | - |
| HPY16_RS14970 | 409319..409636 | - | 318 | WP_046126185.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY16_RS14975 | 409655..409897 | - | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY16_RS14980 | 410355..410468 | + | 114 | Protein_442 | DUF645 family protein | - |
| HPY16_RS14985 | 410675..410950 | + | 276 | WP_000436062.1 | hypothetical protein | - |
| HPY16_RS14990 | 411083..411553 | - | 471 | WP_000784954.1 | RES family NAD+ phosphorylase | - |
| HPY16_RS14995 | 411553..412005 | - | 453 | WP_000024295.1 | DUF2384 domain-containing protein | - |
| HPY16_RS15000 | 412229..412876 | + | 648 | WP_175248434.1 | hypothetical protein | - |
| HPY16_RS15005 | 413012..413392 | + | 381 | WP_032473190.1 | hypothetical protein | - |
| HPY16_RS15010 | 413565..413849 | + | 285 | WP_000048765.1 | antibiotic biosynthesis monooxygenase | - |
| HPY16_RS15015 | 414029..414250 | + | 222 | WP_175248435.1 | DUF1289 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | blaCARB-7 | - | 309435..510278 | 200843 | |
| - | inside | Integron | - | - | 310548..509407 | 198859 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12154.94 Da Isoelectric Point: 9.5427
>T157928 WP_046126185.1 NZ_CP053803:c409636-409319 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSSLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLKHSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSSLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLKHSRFVS
Download Length: 318 bp
>T157928 NZ_CP069517:c1742845-1742591 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGATCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGATCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8931.22 Da Isoelectric Point: 5.6630
>AT157928 WP_000557291.1 NZ_CP053803:c409897-409655 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGAAFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGAAFLNTL
Download Length: 243 bp
>AT157928 NZ_CP069517:c1743093-1742842 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|