Detailed information of TA system TA157927

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 405086..405614
• Replicon: chromosome
• Accession: NZ_CP053803
• Organism: Vibrio cholerae strain L6G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY16_RS14910
• Protein ID: WP_154171015.1
• Coordinates: 405086..405376 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0F2IA58
• Locus tag: HPY16_RS14915
• Protein ID: WP_000126952.1
• Coordinates: 405366..405614 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY16_RS14865	400336..401445	+	1110	WP_175248428.1	DUF4238 domain-containing protein	-
HPY16_RS14870	401460..401552	+	93	WP_075042595.1	DUF3265 domain-containing protein	-
HPY16_RS14875	401583..402350	+	768	WP_055065327.1	FRG domain-containing protein	-
HPY16_RS14880	402407..402475	+	69	Protein_422	acetyltransferase	-
HPY16_RS14885	402485..403000	+	516	WP_175248609.1	GNAT family N-acetyltransferase	-
HPY16_RS14890	403234..403713	+	480	WP_175248429.1	DUF1456 family protein	-
HPY16_RS14895	404007..404096	+	90	WP_001886435.1	DUF645 family protein	-
HPY16_RS14900	404096..404188	+	93	Protein_426	DUF645 family protein	-
HPY16_RS14905	404386..404919	+	534	WP_175248331.1	hypothetical protein	-
HPY16_RS14910	405086..405376	-	291	WP_154171015.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY16_RS14915	405366..405614	-	249	WP_000126952.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY16_RS14920	405671..405781	+	111	WP_099609988.1	DUF3265 domain-containing protein	-
HPY16_RS14925	405958..406176	+	219	WP_044128180.1	DUF3709 domain-containing protein	-
HPY16_RS14930	406454..406969	+	516	WP_175248430.1	hypothetical protein	-
HPY16_RS14935	406971..407087	+	117	WP_081981487.1	DUF3265 domain-containing protein	-
HPY16_RS14940	407273..407455	+	183	WP_000923156.1	DUF645 family protein	-
HPY16_RS14945	407571..407684	+	114	WP_175248431.1	acetyltransferase	-
HPY16_RS14950	407633..407914	+	282	WP_175248432.1	DUF1289 domain-containing protein	-
HPY16_RS14955	408182..408571	+	390	WP_114709500.1	hypothetical protein	-
HPY16_RS14960	408628..408750	+	123	WP_175248433.1	acetyltransferase	-
HPY16_RS14965	408747..409079	-	333	WP_095482527.1	SEC-C domain-containing protein	-
HPY16_RS14970	409319..409636	-	318	WP_046126185.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY16_RS14975	409655..409897	-	243	WP_000557291.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY16_RS14980	410355..410468	+	114	Protein_442	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-7	-	309435..510278	200843
	-	inside	Integron	-	-	310548..509407	198859

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11204.20 Da
• Isoelectric Point: 10.6296

>T157927 WP_154171015.1 NZ_CP053803:c405376-405086 [Vibrio cholerae]
MTYKLDFKKSALKEWKKLGSTLQLQFKKKLIERLENPHVPASKLSGADNMYKIKLRQSGYRLVYQVKDDVIVVTVLAVGK
RERSDVYRSAMKRLDD

Nucleotide

• Length: 291 bp

>T157927 NZ_CP069517:1730949-1731323 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9062.38 Da
• Isoelectric Point: 4.1068

>AT157927 WP_000126952.1 NZ_CP053803:c405614-405366 [Vibrio cholerae]
MTARILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAKAYEMMMDRLDDLELLAIARERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT157927 NZ_CP069517:1730492-1730860 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGAATGTGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACATCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0F2IA58