Detailed information of TA system TA157926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 396191..396701
• Replicon: chromosome
• Accession: NZ_CP053803
• Organism: Vibrio cholerae strain L6G

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0F2IA90
• Locus tag: HPY16_RS14830
• Protein ID: WP_000098716.1
• Coordinates: 396438..396701 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A7Y3QZ95
• Locus tag: HPY16_RS14825
• Protein ID: WP_001223794.1
• Coordinates: 396191..396445 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY16_RS14785	391424..392449	+	1026	WP_175231413.1	hypothetical protein	-
HPY16_RS14790	392445..392567	+	123	WP_175231869.1	DUF3265 domain-containing protein	-
HPY16_RS14795	392603..393019	+	417	WP_175248423.1	ASCH domain-containing protein	-
HPY16_RS14800	393196..394083	+	888	WP_175248424.1	FRG domain-containing protein	-
HPY16_RS14805	394108..394201	+	94	Protein_407	DUF3265 domain-containing protein	-
HPY16_RS14810	394229..394735	+	507	WP_114742457.1	SLATT domain-containing protein	-
HPY16_RS14815	394732..395511	+	780	WP_175248425.1	nucleotidyltransferase	-
HPY16_RS14820	395666..395962	+	297	WP_000617998.1	Dabb family protein	-
HPY16_RS14825	396191..396445	+	255	WP_001223794.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HPY16_RS14830	396438..396701	+	264	WP_000098716.1	Txe/YoeB family addiction module toxin	Toxin
HPY16_RS14835	396871..397146	+	276	WP_000436062.1	hypothetical protein	-
HPY16_RS14840	397292..397573	+	282	WP_103182355.1	hypothetical protein	-
HPY16_RS14845	397646..398110	-	465	WP_017420537.1	hypothetical protein	-
HPY16_RS14850	398676..398789	+	114	Protein_416	DUF645 family protein	-
HPY16_RS14855	398966..399661	+	696	WP_175248426.1	hypothetical protein	-
HPY16_RS14860	399956..400138	+	183	WP_175248427.1	DUF645 family protein	-
HPY16_RS14865	400336..401445	+	1110	WP_175248428.1	DUF4238 domain-containing protein	-
HPY16_RS14870	401460..401552	+	93	WP_075042595.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-7	-	309435..510278	200843
	-	inside	Integron	-	-	310548..509407	198859

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10401.72 Da
• Isoelectric Point: 7.9816

>T157926 WP_000098716.1 NZ_CP053803:396438-396701 [Vibrio cholerae]
MSSRLLSWTDESWDDYLYWQTQDKKTLKRINKIINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDNAITV
ISCRYHY

Nucleotide

• Length: 264 bp

>T157926 NZ_CP069517:c1441621-1441519 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9437.64 Da
• Isoelectric Point: 5.0481

>AT157926 WP_001223794.1 NZ_CP053803:396191-396445 [Vibrio cholerae]
MRIVSFTEARNSLKAVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGKVTQRD
LIDE

Nucleotide

• Length: 255 bp

>AT157926 NZ_CP069517:1441481-1441749 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Toxin

• AlphaFold DB: A0A0F2IA90

Antitoxin

• AlphaFold DB: A0A7Y3QZ95