Detailed information of TA system TA157923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 374721..375487
• Replicon: chromosome
• Accession: NZ_CP053803
• Organism: Vibrio cholerae strain L6G

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HPY16_RS14605
• Protein ID: WP_175246456.1
• Coordinates: 374721..375218 (-)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HPY16_RS14610
• Protein ID: WP_001915058.1
• Coordinates: 375215..375487 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY16_RS14565	369749..370231	+	483	WP_148508397.1	GNAT family N-acetyltransferase	-
HPY16_RS14570	370378..371124	+	747	WP_175248414.1	hypothetical protein	-
HPY16_RS14575	371497..371593	+	97	Protein_361	DUF645 family protein	-
HPY16_RS14580	371788..372252	+	465	WP_000203719.1	N-acetyltransferase	-
HPY16_RS14585	372557..372738	+	182	Protein_363	DUF645 family protein	-
HPY16_RS14590	372916..373371	+	456	WP_001245329.1	GNAT family N-acetyltransferase	-
HPY16_RS14595	373737..373847	+	111	WP_076025930.1	DUF645 family protein	-
HPY16_RS14600	374043..374579	+	537	WP_005526589.1	nucleotidyltransferase family protein	-
HPY16_RS14605	374721..375218	-	498	WP_175246456.1	GNAT family N-acetyltransferase	Toxin
HPY16_RS14610	375215..375487	-	273	WP_001915058.1	DUF1778 domain-containing protein	Antitoxin
HPY16_RS14615	375639..375752	+	114	WP_175248415.1	acetyltransferase	-
HPY16_RS14620	375785..376189	+	405	WP_080388968.1	hypothetical protein	-
HPY16_RS14625	376308..376589	+	282	WP_095474187.1	DUF1289 domain-containing protein	-
HPY16_RS14630	376852..377211	+	360	WP_019830329.1	VOC family protein	-
HPY16_RS14635	377481..377717	+	237	WP_162810550.1	DUF3709 domain-containing protein	-
HPY16_RS14640	377907..378026	+	120	Protein_374	damage-inducible protein DinB	-
HPY16_RS14645	378018..378521	+	504	WP_095477157.1	DinB family protein	-
HPY16_RS14650	378667..379137	+	471	WP_095469162.1	GNAT family N-acetyltransferase	-
HPY16_RS14655	379296..379652	+	357	WP_175248416.1	hypothetical protein	-
HPY16_RS14660	379846..380310	+	465	WP_175248417.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-7	-	309435..510278	200843
	-	inside	Integron	-	-	310548..509407	198859

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-86)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18534.25 Da
• Isoelectric Point: 8.7729

>T157923 WP_175246456.1 NZ_CP053803:c375218-374721 [Vibrio cholerae]
MMNTVLLEKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYEHYGFKAFQDAENKLFITIADI
RASLG

Nucleotide

• Length: 498 bp

>T157923 NZ_CP069517:c887915-887808 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9655.16 Da
• Isoelectric Point: 6.2988

>AT157923 WP_001915058.1 NZ_CP053803:c375487-375215 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Nucleotide

• Length: 273 bp

>AT157923 NZ_CP069517:887968-888029 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT