Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 318466..318994 | Replicon | chromosome |
| Accession | NZ_CP053803 | ||
| Organism | Vibrio cholerae strain L6G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | HPY16_RS14115 | Protein ID | WP_175248386.1 |
| Coordinates | 318466..318756 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | H9L4T4 |
| Locus tag | HPY16_RS14120 | Protein ID | WP_000213183.1 |
| Coordinates | 318746..318994 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY16_RS14060 | 313910..314128 | + | 219 | WP_044128180.1 | DUF3709 domain-containing protein | - |
| HPY16_RS14065 | 314351..314511 | + | 161 | Protein_259 | hypothetical protein | - |
| HPY16_RS14070 | 314529..314789 | + | 261 | WP_175247664.1 | DUF3709 domain-containing protein | - |
| HPY16_RS14075 | 315014..315313 | - | 300 | WP_000802138.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY16_RS14080 | 315310..315552 | - | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| HPY16_RS14085 | 315774..316007 | + | 234 | WP_000233292.1 | hypothetical protein | - |
| HPY16_RS14090 | 316237..316518 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY16_RS14095 | 316515..316802 | + | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY16_RS14100 | 316964..317350 | + | 387 | WP_000703159.1 | VOC family protein | - |
| HPY16_RS14105 | 317590..317826 | + | 237 | WP_002051081.1 | DUF645 family protein | - |
| HPY16_RS14110 | 318027..318323 | + | 297 | WP_000617998.1 | Dabb family protein | - |
| HPY16_RS14115 | 318466..318756 | - | 291 | WP_175248386.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY16_RS14120 | 318746..318994 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY16_RS14125 | 319338..319520 | + | 183 | WP_175248387.1 | DUF645 family protein | - |
| HPY16_RS14130 | 319883..320049 | + | 167 | Protein_272 | DUF645 family protein | - |
| HPY16_RS14135 | 320407..320535 | + | 129 | WP_080551848.1 | DUF645 family protein | - |
| HPY16_RS14140 | 320551..320589 | + | 39 | WP_113629368.1 | hypothetical protein | - |
| HPY16_RS14145 | 320788..321330 | + | 543 | WP_142738652.1 | yfeABCD locus regulator | - |
| HPY16_RS14150 | 321637..321818 | + | 182 | Protein_276 | DUF645 family protein | - |
| HPY16_RS14155 | 322014..322460 | + | 447 | WP_000006157.1 | hypothetical protein | - |
| HPY16_RS14160 | 322608..323123 | + | 516 | WP_175248388.1 | ClbS/DfsB family four-helix bundle protein | - |
| HPY16_RS14165 | 323193..323255 | + | 63 | Protein_279 | acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | blaCARB-7 | - | 309435..510278 | 200843 | |
| - | inside | Integron | - | - | 310548..509407 | 198859 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11175.17 Da Isoelectric Point: 10.5708
>T157920 WP_175248386.1 NZ_CP053803:c318756-318466 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIGRLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIGRLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T157920 NZ_CP069510:c1836995-1836597 [Haemophilus parahaemolyticus]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGACCATTGGAAGTTCTTTCTCGCTTTAA
TCAAAATGCAGGGAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACCTTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAAAGAATTTGAGCGAGTTCCCGCATTGCGTACAGAAAATTGGGTGTAA
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGACCATTGGAAGTTCTTTCTCGCTTTAA
TCAAAATGCAGGGAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACCTTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAAAGAATTTGAGCGAGTTCCCGCATTGCGTACAGAAAATTGGGTGTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8937.28 Da Isoelectric Point: 4.1079
>AT157920 WP_000213183.1 NZ_CP053803:c318994-318746 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT157920 NZ_CP069510:c1837228-1836995 [Haemophilus parahaemolyticus]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCCGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATTAGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCCGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATTAGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|