Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 316237..316802 | Replicon | chromosome |
| Accession | NZ_CP053803 | ||
| Organism | Vibrio cholerae strain L6G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | HPY16_RS14095 | Protein ID | WP_000869999.1 |
| Coordinates | 316515..316802 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | HPY16_RS14090 | Protein ID | WP_000086649.1 |
| Coordinates | 316237..316518 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY16_RS14045 | 312321..312491 | + | 171 | WP_001080654.1 | hypothetical protein | - |
| HPY16_RS14050 | 312491..312892 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| HPY16_RS14055 | 313046..313624 | + | 579 | WP_175248385.1 | hypothetical protein | - |
| HPY16_RS14060 | 313910..314128 | + | 219 | WP_044128180.1 | DUF3709 domain-containing protein | - |
| HPY16_RS14065 | 314351..314511 | + | 161 | Protein_259 | hypothetical protein | - |
| HPY16_RS14070 | 314529..314789 | + | 261 | WP_175247664.1 | DUF3709 domain-containing protein | - |
| HPY16_RS14075 | 315014..315313 | - | 300 | WP_000802138.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY16_RS14080 | 315310..315552 | - | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| HPY16_RS14085 | 315774..316007 | + | 234 | WP_000233292.1 | hypothetical protein | - |
| HPY16_RS14090 | 316237..316518 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY16_RS14095 | 316515..316802 | + | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY16_RS14100 | 316964..317350 | + | 387 | WP_000703159.1 | VOC family protein | - |
| HPY16_RS14105 | 317590..317826 | + | 237 | WP_002051081.1 | DUF645 family protein | - |
| HPY16_RS14110 | 318027..318323 | + | 297 | WP_000617998.1 | Dabb family protein | - |
| HPY16_RS14115 | 318466..318756 | - | 291 | WP_175248386.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY16_RS14120 | 318746..318994 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY16_RS14125 | 319338..319520 | + | 183 | WP_175248387.1 | DUF645 family protein | - |
| HPY16_RS14130 | 319883..320049 | + | 167 | Protein_272 | DUF645 family protein | - |
| HPY16_RS14135 | 320407..320535 | + | 129 | WP_080551848.1 | DUF645 family protein | - |
| HPY16_RS14140 | 320551..320589 | + | 39 | WP_113629368.1 | hypothetical protein | - |
| HPY16_RS14145 | 320788..321330 | + | 543 | WP_142738652.1 | yfeABCD locus regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | blaCARB-7 | - | 309435..510278 | 200843 | |
| - | inside | Integron | - | - | 310548..509407 | 198859 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T157919 WP_000869999.1 NZ_CP053803:316515-316802 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T157919 NZ_CP069510:1529158-1529442 [Haemophilus parahaemolyticus]
ATGGAATCAGTTAAAACATTAAAAGTAACTGCAACTAAAACATTTCAACGAGATATTAAAAAGCTCACAGCTAAGCAACA
ATTCTCAGTAGAAATGACCGAGGTTTTGTATCTTTTACAAAGAAATCGACCGCTTCCAAGAAAATATTTAGACCACGCAC
TACAAGGCGAAATGCAAGGTTATCGTAACTGCCATATTTTTAGCGATCTTGTGCTGATTTACCAAATTATTGATGACAAA
GAATTAAAGCTCATTCGTATCGGTTCACATTCGGAAATTTTCTAA
ATGGAATCAGTTAAAACATTAAAAGTAACTGCAACTAAAACATTTCAACGAGATATTAAAAAGCTCACAGCTAAGCAACA
ATTCTCAGTAGAAATGACCGAGGTTTTGTATCTTTTACAAAGAAATCGACCGCTTCCAAGAAAATATTTAGACCACGCAC
TACAAGGCGAAATGCAAGGTTATCGTAACTGCCATATTTTTAGCGATCTTGTGCTGATTTACCAAATTATTGATGACAAA
GAATTAAAGCTCATTCGTATCGGTTCACATTCGGAAATTTTCTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT157919 WP_000086649.1 NZ_CP053803:316237-316518 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT157919 NZ_CP069510:1528871-1529152 [Haemophilus parahaemolyticus]
ATGACACAAAATGCATCTTTTAGCTTTCGTTTATCAGAAAATTTAAAACAAGAGGCTTTTAATGTAATTGAAAATTACGG
TTTCACCCCTTCGCAAGTGTTTAATTTATTCTTAACAGAAATTGCGAATACAAAAACGATTCCAGTAAACCTTTCTTATT
TGAAACCAAATGCTGAAACATTACGCGCTATGCAAGAAGCTGAAAATGGTGATGTTGATATCATTAGTGAAGCAAATTTC
GAAGCCAACATTATGGAAAATCTATTAAAATCAGTGAAATAA
ATGACACAAAATGCATCTTTTAGCTTTCGTTTATCAGAAAATTTAAAACAAGAGGCTTTTAATGTAATTGAAAATTACGG
TTTCACCCCTTCGCAAGTGTTTAATTTATTCTTAACAGAAATTGCGAATACAAAAACGATTCCAGTAAACCTTTCTTATT
TGAAACCAAATGCTGAAACATTACGCGCTATGCAAGAAGCTGAAAATGGTGATGTTGATATCATTAGTGAAGCAAATTTC
GAAGCCAACATTATGGAAAATCTATTAAAATCAGTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3AEF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UIW4 |