157918

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 315014..315552 Replicon chromosome
Accession NZ_CP053803
Organism Vibrio cholerae strain L6G

Toxin (Protein)


Gene name parE Uniprot ID A0A0K9UM73
Locus tag HPY16_RS14075 Protein ID WP_000802138.1
Coordinates 315014..315313 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A271VK51
Locus tag HPY16_RS14080 Protein ID WP_001107720.1
Coordinates 315310..315552 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY16_RS14035 310113..310466 + 354 WP_001138366.1 50S ribosomal protein L20 -
HPY16_RS14040 310548..311510 - 963 WP_114736117.1 integron integrase IntIA -
HPY16_RS14045 312321..312491 + 171 WP_001080654.1 hypothetical protein -
HPY16_RS14050 312491..312892 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
HPY16_RS14055 313046..313624 + 579 WP_175248385.1 hypothetical protein -
HPY16_RS14060 313910..314128 + 219 WP_044128180.1 DUF3709 domain-containing protein -
HPY16_RS14065 314351..314511 + 161 Protein_259 hypothetical protein -
HPY16_RS14070 314529..314789 + 261 WP_175247664.1 DUF3709 domain-containing protein -
HPY16_RS14075 315014..315313 - 300 WP_000802138.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY16_RS14080 315310..315552 - 243 WP_001107720.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HPY16_RS14085 315774..316007 + 234 WP_000233292.1 hypothetical protein -
HPY16_RS14090 316237..316518 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY16_RS14095 316515..316802 + 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY16_RS14100 316964..317350 + 387 WP_000703159.1 VOC family protein -
HPY16_RS14105 317590..317826 + 237 WP_002051081.1 DUF645 family protein -
HPY16_RS14110 318027..318323 + 297 WP_000617998.1 Dabb family protein -
HPY16_RS14115 318466..318756 - 291 WP_175248386.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY16_RS14120 318746..318994 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY16_RS14125 319338..319520 + 183 WP_175248387.1 DUF645 family protein -
HPY16_RS14130 319883..320049 + 167 Protein_272 DUF645 family protein -
HPY16_RS14135 320407..320535 + 129 WP_080551848.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCARB-7 - 309435..510278 200843
- inside Integron - - 310548..509407 198859


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11617.34 Da        Isoelectric Point: 9.8184

>T157918 WP_000802138.1 NZ_CP053803:c315313-315014 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKYPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T157918 NZ_CP069510:1452127-1452474 [Haemophilus parahaemolyticus]
ATGAAATTAACTTTTATCGAATTACCACCCTTTGAACGATATCGAAAAGAACATATTAGTGATGAAGCGTATCGACTTTT
CCAAAATGAACTATTAGATAATCCAGAGAAAGGTGATGTTATTCAAGGAACAGGCGGGTTAAGAAAAATTCGATTAGCTG
ATCATTCTCGTCATAAAGGTAAACGAGGAGGAGCAAGGGCAATTTACCATTATTTTGTTAATGGTAATCAGATTTGGCTT
TTTGCCGTTTATGGAAAAGGCGAAAAAGAGGATTTAAACGAAACGGAAAAAAGAACGTTTAAAGTTGTTTTAGAAAACTT
AAAAGCATTAGCAAGGGGGAATAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.82 Da        Isoelectric Point: 4.1677

>AT157918 WP_001107720.1 NZ_CP053803:c315552-315310 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT157918 NZ_CP069510:1452471-1452779 [Haemophilus parahaemolyticus]
ATGAGCCGTTTATTTGACGATTTAATGGAAGGGGCAAAAGCACTCGAAGATCACTTACAAGGCAAAATCACATTACGCAC
CGAGACGCTTGAAAAATCAGAGCCTGTGACGATCAGTGCCAACGAAGTGAAAGCTATTCGTGAAAAATTAAATTTATCTC
AAGCAGTATTTGCTCATCGTTTGAGAACAAGCGTGAGAACCTATCAAGGTTGGGAGCAAGGAAAAACAAAACCGAATCCA
CAAGCCGCATTATTATTAAGAATGGTTGAACATTCACCGCAAACATTTAATTTAATCGTTGGCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UM73

Antitoxin

Source ID Structure
AlphaFold DB A0A271VK51

References