Detailed information of TA system TA157917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 312321..312892
• Replicon: chromosome
• Accession: NZ_CP053803
• Organism: Vibrio cholerae strain L6G

Toxin (Protein)

• Gene name: doc
• Uniprot ID: Q9KMA2
• Locus tag: HPY16_RS14050
• Protein ID: WP_000351248.1
• Coordinates: 312491..312892 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: Q8GNG3
• Locus tag: HPY16_RS14045
• Protein ID: WP_001080654.1
• Coordinates: 312321..312491 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY16_RS14025	309222..309773	+	552	WP_001894072.1	translation initiation factor IF-3	-
HPY16_RS14030	309877..310071	+	195	WP_001885060.1	50S ribosomal protein L35	-
HPY16_RS14035	310113..310466	+	354	WP_001138366.1	50S ribosomal protein L20	-
HPY16_RS14040	310548..311510	-	963	WP_114736117.1	integron integrase IntIA	-
HPY16_RS14045	312321..312491	+	171	WP_001080654.1	hypothetical protein	Antitoxin
HPY16_RS14050	312491..312892	+	402	WP_000351248.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
HPY16_RS14055	313046..313624	+	579	WP_175248385.1	hypothetical protein	-
HPY16_RS14060	313910..314128	+	219	WP_044128180.1	DUF3709 domain-containing protein	-
HPY16_RS14065	314351..314511	+	161	Protein_259	hypothetical protein	-
HPY16_RS14070	314529..314789	+	261	WP_175247664.1	DUF3709 domain-containing protein	-
HPY16_RS14075	315014..315313	-	300	WP_000802138.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY16_RS14080	315310..315552	-	243	WP_001107720.1	type II toxin-antitoxin system ParD family antitoxin	-
HPY16_RS14085	315774..316007	+	234	WP_000233292.1	hypothetical protein	-
HPY16_RS14090	316237..316518	+	282	WP_000086649.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY16_RS14095	316515..316802	+	288	WP_000869999.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY16_RS14100	316964..317350	+	387	WP_000703159.1	VOC family protein	-
HPY16_RS14105	317590..317826	+	237	WP_002051081.1	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-7	-	309435..510278	200843
	-	inside	Integron	-	-	310548..509407	198859

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-132)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14608.71 Da
• Isoelectric Point: 4.0128

>T157917 WP_000351248.1 NZ_CP053803:312491-312892 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Nucleotide

• Length: 402 bp

>T157917 NZ_CP069510:1411912-1412076 [Haemophilus parahaemolyticus]
ATGTTTGAATACGACCCTAATAAAAGTGAAATAAAATTAGGTATAGCAAAACTCAATGATAAACACTGGTCTGCTATATT
TACATTACGTGGTAAAAACATCCGTCTTATCTCTGTTAGACGATCTCGAAAAAAGGAAATTGAACTTTATGAAACCAATC
AATAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6287.35 Da
• Isoelectric Point: 10.7274

>AT157917 WP_001080654.1 NZ_CP053803:312321-312491 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Nucleotide

• Length: 171 bp

>AT157917 NZ_CP069510:1412060-1412314 [Haemophilus parahaemolyticus]
ATGAAACCAATCAATAATATCGAATTCGATCATATCTTCGATGAAAATGAAGAAGATATTGTGGAATATCTAGAGCTTAC
ATCGGCTAAACGCCCAAACCAAAAAACAAAACGTGTTAATGTTGATTTTCCATTATGGATGGTTGAAAGTTTAGATAAAG
AAGCGGCTCATCTCGGCGTTCCTCGTCAGGCTCTAATTAAACTATGGATTTCTGAAAAGTTACCCGTATATAAAAACCAC
CTTCAAACCGCATAA

Structures

Toxin

• AlphaFold DB: A0A0Q0PN34

Antitoxin

• AlphaFold DB: A0A1T4SJJ1