Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2088970..2090795 Replicon chromosome
Accession NZ_CP053802
Organism Vibrio cholerae strain L6G

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HPY16_RS09330 Protein ID WP_142993673.1
Coordinates 2088970..2090331 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HPY16_RS09335 Protein ID WP_175248208.1
Coordinates 2090328..2090795 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY16_RS09300 2084504..2086168 + 1665 WP_113629212.1 DNA repair protein RecN -
HPY16_RS09305 2086327..2086686 + 360 WP_001160907.1 outer membrane protein assembly factor BamE -
HPY16_RS09310 2086762..2087067 - 306 WP_175248207.1 RnfH family protein -
HPY16_RS09315 2087070..2087504 - 435 WP_000815880.1 type II toxin-antitoxin system RatA family toxin -
HPY16_RS09320 2087688..2088173 + 486 WP_000162689.1 SsrA-binding protein SmpB -
HPY16_RS09330 2088970..2090331 + 1362 WP_142993673.1 type II toxin-antitoxin system HipA family toxin Toxin
HPY16_RS09335 2090328..2090795 + 468 WP_175248208.1 helix-turn-helix domain-containing protein Antitoxin
HPY16_RS09340 2091376..2093394 + 2019 WP_175248209.1 DNA phosphorothioation-associated putative methyltransferase -
HPY16_RS09345 2093617..2094696 + 1080 WP_175248210.1 DNA sulfur modification protein DndB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51331.23 Da        Isoelectric Point: 4.8586

>T157916 WP_142993673.1 NZ_CP053802:2088970-2090331 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T157916 NZ_CP069510:550123-550308 [Haemophilus parahaemolyticus]
ATGCGATCCAGCGACTTAATCAAGGAGCTTAAAAAAGCAGGTTGCACGTTTGAGCGACACGGTAAGGGAGACCACCAAAT
TTGGAAATCGCCCATCACAGGGAAGACGTTCCCCGTGCCACACCCAAAGCAACACGTTCCAATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTTTATAG

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17061.54 Da        Isoelectric Point: 10.7084

>AT157916 WP_175248208.1 NZ_CP053802:2090328-2090795 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDLFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT157916 NZ_CP069510:550339-550767 [Haemophilus parahaemolyticus]
ATGTTATTTACTATCGGCATTGAAACCCCAGCAAACGAAAACGAAGCCTACGGCATTGCCGTGCCAGCACTTTCTACTGA
AAAATATGATTGCTTTAGTGCTGCAGATACCCTTGAAGAAATTCCAACCCAAGCCACTGATGCCATTCATTCCATCTTAG
AAATGATGTTTGAAGACGGCTTAGATATCAATGAACTACAAGATAAAGGCTATCGCCACTATCAAACGCTTGAAGATTTC
AACTATTGCGATACTTGGCTTCTGCTTGATGTTGACATTTCCGCTTATCAAGGTAAACGTCACCGCATTAACATCAGCTT
GCCTGAATACCTCATCAAACGCATTGATAGCCGTGTCGCAAGCAACCCGATTTACAAAGACCGCAGCCACTTTTTAGCAG
TGGCTTCACAAAAAGAGTTAAGACAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References