Detailed information of TA system TA157916

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2088970..2090795
• Replicon: chromosome
• Accession: NZ_CP053802
• Organism: Vibrio cholerae strain L6G

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HPY16_RS09330
• Protein ID: WP_142993673.1
• Coordinates: 2088970..2090331 (+)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HPY16_RS09335
• Protein ID: WP_175248208.1
• Coordinates: 2090328..2090795 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY16_RS09300	2084504..2086168	+	1665	WP_113629212.1	DNA repair protein RecN	-
HPY16_RS09305	2086327..2086686	+	360	WP_001160907.1	outer membrane protein assembly factor BamE	-
HPY16_RS09310	2086762..2087067	-	306	WP_175248207.1	RnfH family protein	-
HPY16_RS09315	2087070..2087504	-	435	WP_000815880.1	type II toxin-antitoxin system RatA family toxin	-
HPY16_RS09320	2087688..2088173	+	486	WP_000162689.1	SsrA-binding protein SmpB	-
HPY16_RS09330	2088970..2090331	+	1362	WP_142993673.1	type II toxin-antitoxin system HipA family toxin	Toxin
HPY16_RS09335	2090328..2090795	+	468	WP_175248208.1	helix-turn-helix domain-containing protein	Antitoxin
HPY16_RS09340	2091376..2093394	+	2019	WP_175248209.1	DNA phosphorothioation-associated putative methyltransferase	-
HPY16_RS09345	2093617..2094696	+	1080	WP_175248210.1	DNA sulfur modification protein DndB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-385)

Antitoxin

• Cro/C1-type helix-turn-helix domain (80-138)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51331.23 Da
• Isoelectric Point: 4.8586

>T157916 WP_142993673.1 NZ_CP053802:2088970-2090331 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Nucleotide

• Length: 1362 bp

>T157916 NZ_CP069510:550123-550308 [Haemophilus parahaemolyticus]
ATGCGATCCAGCGACTTAATCAAGGAGCTTAAAAAAGCAGGTTGCACGTTTGAGCGACACGGTAAGGGAGACCACCAAAT
TTGGAAATCGCCCATCACAGGGAAGACGTTCCCCGTGCCACACCCAAAGCAACACGTTCCAATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTTTATAG

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17061.54 Da
• Isoelectric Point: 10.7084

>AT157916 WP_175248208.1 NZ_CP053802:2090328-2090795 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDLFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Nucleotide

• Length: 468 bp

>AT157916 NZ_CP069510:550339-550767 [Haemophilus parahaemolyticus]
ATGTTATTTACTATCGGCATTGAAACCCCAGCAAACGAAAACGAAGCCTACGGCATTGCCGTGCCAGCACTTTCTACTGA
AAAATATGATTGCTTTAGTGCTGCAGATACCCTTGAAGAAATTCCAACCCAAGCCACTGATGCCATTCATTCCATCTTAG
AAATGATGTTTGAAGACGGCTTAGATATCAATGAACTACAAGATAAAGGCTATCGCCACTATCAAACGCTTGAAGATTTC
AACTATTGCGATACTTGGCTTCTGCTTGATGTTGACATTTCCGCTTATCAAGGTAAACGTCACCGCATTAACATCAGCTT
GCCTGAATACCTCATCAAACGCATTGATAGCCGTGTCGCAAGCAACCCGATTTACAAAGACCGCAGCCACTTTTTAGCAG
TGGCTTCACAAAAAGAGTTAAGACAATAA