Detailed information of TA system TA157915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 424872..425437
• Replicon: chromosome
• Accession: NZ_CP053801
• Organism: Vibrio cholerae strain SO5Y

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0F2IXR1
• Locus tag: HPY15_RS15660
• Protein ID: WP_017049660.1
• Coordinates: 425150..425437 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W9USL4
• Locus tag: HPY15_RS15655
• Protein ID: WP_000086650.1
• Coordinates: 424872..425153 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY15_RS15625	420304..421263	-	960	WP_001898459.1	IS30 family transposase	-
HPY15_RS15630	421418..422272	+	855	WP_142741583.1	aminoglycoside phosphotransferase family protein	-
HPY15_RS15635	422412..422690	-	279	WP_000578471.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
HPY15_RS15640	422687..422971	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
HPY15_RS15645	423300..424232	+	933	WP_046126168.1	hypothetical protein	-
HPY15_RS15650	424216..424644	+	429	WP_000074666.1	hypothetical protein	-
HPY15_RS15655	424872..425153	+	282	WP_000086650.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY15_RS15660	425150..425437	+	288	WP_017049660.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY15_RS15665	425605..426609	+	1005	WP_046126167.1	LD-carboxypeptidase	-
HPY15_RS15670	427026..427946	-	921	WP_001896359.1	IS5-like element ISVch8 family transposase	-
HPY15_RS15675	428812..429093	-	282	WP_080284439.1	DUF1289 domain-containing protein	-
HPY15_RS15680	429042..429155	-	114	WP_080341667.1	acetyltransferase	-
HPY15_RS15685	429212..429769	-	558	WP_046126164.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	296008..431802	135794
	-	inside	Integron	-	-	382712..427017	44305

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10929.71 Da
• Isoelectric Point: 5.6023

>T157915 WP_017049660.1 NZ_CP053801:425150-425437 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNDVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T157915 NZ_CP069510:c379540-379181 [Haemophilus parahaemolyticus]
ATGAAAAAACAATCTCAATGGACGGTAATCGCTACTGAACGATTTAATCTCTGGCTGCTTGAGCAAACCGAAGATGTTCG
TCAATCGGTGTTTGCATCGCTCAATAACTTGAAAATGTATGGTTACCAGCTTTCACGTCCTTATGCTGACACGATAAAAG
GCTCAAAATATCCGAATATGAAAGAACTTCGCATTCAGCATAAAGGCAAGCCGTTGCGAGCGTTTTTCGCTTTCGACCCA
CTTAGACAAGCTATTGTGCTCTGTGCGGGGGATAAAAGTAACGACAAACAATTTTATGAGCGAATGATTAAAATCGCCGA
TGCAGAATTTACCGACTACTTACAAAGTTTGGAGCAATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10347.90 Da
• Isoelectric Point: 5.1548

>AT157915 WP_000086650.1 NZ_CP053801:424872-425153 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK

Nucleotide

• Length: 282 bp

>AT157915 NZ_CP069510:c379170-378871 [Haemophilus parahaemolyticus]
ATGTACACCCTTGAAGAGATGATTGCCCGTGAAACACCTGAGTCTCAACAAAAAATCAAAGAGATGTCCGATGAACTGAT
TTTAGAAACAGGGCTTGCGATGATTCGTGAAAACCTAGCATTGTCGCAAAAAGAGATGGCTCAAGCCGTAGGTGTATCTC
AATCCGCGATTGCTCAGATTGAACAGCGTGGCAATGATGTTAAACTCTCTACACTTAAACGCTACATTGAGAAAATGGGC
GGTGAACTCAGCCTTGCCGTCAAAATGCCAACAGGTTACAGCCAGATTTTTCCAATTTAA

Structures

Toxin

• AlphaFold DB: A0A0F2IXR1

Antitoxin

• AlphaFold DB: W9USL4