Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 422412..422971 | Replicon | chromosome |
| Accession | NZ_CP053801 | ||
| Organism | Vibrio cholerae strain SO5Y | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HHK2 |
| Locus tag | HPY15_RS15635 | Protein ID | WP_000578471.1 |
| Coordinates | 422412..422690 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | HPY15_RS15640 | Protein ID | WP_000381183.1 |
| Coordinates | 422687..422971 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY15_RS15600 | 417939..418058 | + | 120 | WP_114780049.1 | acetyltransferase | - |
| HPY15_RS15605 | 417999..418316 | - | 318 | WP_000077272.1 | CcdB family protein | - |
| HPY15_RS15610 | 418316..418561 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| HPY15_RS15615 | 418929..419486 | + | 558 | Protein_441 | nucleotidyltransferase domain-containing protein | - |
| HPY15_RS15620 | 419619..420281 | + | 663 | WP_076008610.1 | Vat family streptogramin A O-acetyltransferase | - |
| HPY15_RS15625 | 420304..421263 | - | 960 | WP_001898459.1 | IS30 family transposase | - |
| HPY15_RS15630 | 421418..422272 | + | 855 | WP_142741583.1 | aminoglycoside phosphotransferase family protein | - |
| HPY15_RS15635 | 422412..422690 | - | 279 | WP_000578471.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| HPY15_RS15640 | 422687..422971 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HPY15_RS15645 | 423300..424232 | + | 933 | WP_046126168.1 | hypothetical protein | - |
| HPY15_RS15650 | 424216..424644 | + | 429 | WP_000074666.1 | hypothetical protein | - |
| HPY15_RS15655 | 424872..425153 | + | 282 | WP_000086650.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY15_RS15660 | 425150..425437 | + | 288 | WP_017049660.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY15_RS15665 | 425605..426609 | + | 1005 | WP_046126167.1 | LD-carboxypeptidase | - |
| HPY15_RS15670 | 427026..427946 | - | 921 | WP_001896359.1 | IS5-like element ISVch8 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 296008..431802 | 135794 | |
| - | inside | Integron | - | - | 382712..427017 | 44305 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10838.56 Da Isoelectric Point: 4.6794
>T157914 WP_000578471.1 NZ_CP053801:c422690-422412 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T157914 NZ_CP069510:c358956-358651 [Haemophilus parahaemolyticus]
ATGATTAACCTAACCGCCTCACATTTTCGTGATGATTATCTCTACCGCTTTTACCAATTTGGCGAAAGTCACAGTAAAAT
TCCTGCGAACCTAACCAATGTGCTTGCTCGCAAATTGGATATGATCAACGCAGCCGAAAACATCAACGATTTACGAGTGC
CACCAGCTAACCACCTTGAACTACTCGAACCGAAAGAGAATAAAATCTATTCCATTCGAGTGAATAAACAGTACCGTCTG
ATTTTCAAATTTGAAAACGGCACACTGTCCGATTTATTTTTAGATCCGCATACATACGCACTATAA
ATGATTAACCTAACCGCCTCACATTTTCGTGATGATTATCTCTACCGCTTTTACCAATTTGGCGAAAGTCACAGTAAAAT
TCCTGCGAACCTAACCAATGTGCTTGCTCGCAAATTGGATATGATCAACGCAGCCGAAAACATCAACGATTTACGAGTGC
CACCAGCTAACCACCTTGAACTACTCGAACCGAAAGAGAATAAAATCTATTCCATTCGAGTGAATAAACAGTACCGTCTG
ATTTTCAAATTTGAAAACGGCACACTGTCCGATTTATTTTTAGATCCGCATACATACGCACTATAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT157914 WP_000381183.1 NZ_CP053801:c422971-422687 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT157914 NZ_CP069510:c358635-358312 [Haemophilus parahaemolyticus]
ATTACAGAACGCAAACCAACCAGTGTAGGCGAAATCCTACTAGAAGAATTTTTAGAACCACTTAACTTAAAAGTAGGCGA
TTTAGCTCAAATTCTTGACGTACATCGCAACACCGCCAGCAGCCTAATCAATAACAACACTCGCATTAGCTTAGAAATGG
CGGTTAAACTCTCGAAAGCGTTCAGTACCAGCCCTGAATTTTGGCTGAACCTACAAACTGCCGTGGATTTATGGGAACTC
AACCACAACAAACGCTTTCAGCAAACATTAGCGAACGTGCGAGTAGCGAATCAATGGCAAGCAATGCCAGCTTTTGCAAT
GTAA
ATTACAGAACGCAAACCAACCAGTGTAGGCGAAATCCTACTAGAAGAATTTTTAGAACCACTTAACTTAAAAGTAGGCGA
TTTAGCTCAAATTCTTGACGTACATCGCAACACCGCCAGCAGCCTAATCAATAACAACACTCGCATTAGCTTAGAAATGG
CGGTTAAACTCTCGAAAGCGTTCAGTACCAGCCCTGAATTTTGGCTGAACCTACAAACTGCCGTGGATTTATGGGAACTC
AACCACAACAAACGCTTTCAGCAAACATTAGCGAACGTGCGAGTAGCGAATCAATGGCAAGCAATGCCAGCTTTTGCAAT
GTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A271VKS2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |