Detailed information of TA system TA157913

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-phd/YoeB(toxin)
• Location: 414891..415341
• Replicon: chromosome
• Accession: NZ_CP053801
• Organism: Vibrio cholerae strain SO5Y

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0F2IA90
• Locus tag: HPY15_RS15575
• Protein ID: WP_000098716.1
• Coordinates: 414891..415154 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: HPY15_RS15580
• Protein ID: WP_080341671.1
• Coordinates: 415234..415341 (+)
• Length: 36 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY15_RS15535	410081..410251	+	171	WP_046127315.1	hypothetical protein	-
HPY15_RS15540	410251..410652	+	402	WP_046126173.1	type II toxin-antitoxin system death-on-curing family toxin	-
HPY15_RS15545	410792..411127	+	336	WP_019829648.1	hypothetical protein	-
HPY15_RS15550	411321..411465	+	145	Protein_428	DUF3709 domain-containing protein	-
HPY15_RS15555	412242..412655	+	414	WP_046126172.1	VOC family protein	-
HPY15_RS15560	412889..413911	+	1023	WP_046126171.1	hypothetical protein	-
HPY15_RS15565	413952..414434	+	483	WP_001900268.1	hypothetical protein	-
HPY15_RS15570	414644..414898	+	255	WP_001223794.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
HPY15_RS15575	414891..415154	+	264	WP_000098716.1	Txe/YoeB family addiction module toxin	Toxin
HPY15_RS15580	415234..415341	+	108	WP_080341671.1	acetyltransferase	Antitoxin
HPY15_RS15585	415769..416707	+	939	WP_055032204.1	5'-nucleotidase	-
HPY15_RS15590	417000..417182	+	183	WP_009355233.1	DUF645 family protein	-
HPY15_RS15595	417385..417882	+	498	WP_046126169.1	GNAT family N-acetyltransferase	-
HPY15_RS15600	417939..418058	+	120	WP_114780049.1	acetyltransferase	-
HPY15_RS15605	417999..418316	-	318	WP_000077272.1	CcdB family protein	-
HPY15_RS15610	418316..418561	-	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-
HPY15_RS15615	418929..419486	+	558	Protein_441	nucleotidyltransferase domain-containing protein	-
HPY15_RS15620	419619..420281	+	663	WP_076008610.1	Vat family streptogramin A O-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	296008..431802	135794
	-	inside	Integron	-	-	382712..427017	44305

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10401.72 Da
• Isoelectric Point: 7.9816

>T157913 WP_000098716.1 NZ_CP053801:414891-415154 [Vibrio cholerae]
MSSRLLSWTDESWDDYLYWQTQDKKTLKRINKIINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDNAITV
ISCRYHY

Nucleotide

• Length: 264 bp

>T157913 NZ_CP069510:c112751-112500 [Haemophilus parahaemolyticus]
ATGCAAGCTATTTCTTATTCACAAGCCCGTCAAACTTTAGCCAAAACAATGACTTCAGTCGTGGAAAATTATGAACCTGT
GCTAATCACTCGCACTACGGGCGAAGATTGTGTGCTTATTTCTCTAGCACATTATCGTTCACTAGAGGAAACTGCTTATT
TGCTTCGTTCGCCTGCCAATGCTCAACACTTACTTTCAGCCATTGAGCAACTTCACCAAAATGAAGGGCAAGAGAGGGAA
TTGATTGAATGA

Antitoxin

Protein

• Length: 36 a.a.
• Molecular weight: 4030.01 Da
• Isoelectric Point: 11.3793

>AT157913 WP_080341671.1 NZ_CP053801:415234-415341 [Vibrio cholerae]
VVTVVVFKFSVMRCQPLRRALCAFLLNTPFLLIHP

Nucleotide

• Length: 108 bp

>AT157913 NZ_CP069510:c112503-112249 [Haemophilus parahaemolyticus]
ATGAAATTGACCTTTGCCGACACCGCTTGGGAAGATTATTTATATTGGCAAGCCACCGACAAAAAACAACTAAAACGCAC
CAATAATCTCATCAAGGATATTCAACGAACGCCTTTTGAAGGTATAGGAAAACCTGAATCATTGAAGTTTCATTTAAGTG
GTTTTTGGTCTCGTCGAATTGATGAAAAACACAGGCTGGTTTATGCCGTAACTGATGAAGCAATTTTAATTGCTTCTTGT
CGTTATCATTACTAA

Structures

Toxin

• AlphaFold DB: A0A0F2IA90