Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
| Location | 410081..410652 | Replicon | chromosome |
| Accession | NZ_CP053801 | ||
| Organism | Vibrio cholerae strain SO5Y | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | HPY15_RS15540 | Protein ID | WP_046126173.1 |
| Coordinates | 410251..410652 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A544N0N8 |
| Locus tag | HPY15_RS15535 | Protein ID | WP_046127315.1 |
| Coordinates | 410081..410251 (+) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY15_RS15490 | 405377..405790 | + | 414 | WP_000451552.1 | GNAT family N-acetyltransferase | - |
| HPY15_RS15495 | 405965..406360 | + | 396 | WP_046126178.1 | DUF3465 domain-containing protein | - |
| HPY15_RS15500 | 406615..406851 | + | 237 | WP_046126177.1 | hypothetical protein | - |
| HPY15_RS15505 | 407180..407350 | + | 171 | WP_032473200.1 | DUF645 family protein | - |
| HPY15_RS15510 | 407578..408081 | + | 504 | WP_046126176.1 | DinB family protein | - |
| HPY15_RS15515 | 408138..408224 | + | 87 | WP_167335580.1 | acetyltransferase | - |
| HPY15_RS15520 | 408274..408468 | + | 195 | WP_046126175.1 | hypothetical protein | - |
| HPY15_RS15525 | 408477..409397 | - | 921 | WP_001896359.1 | IS5-like element ISVch8 family transposase | - |
| HPY15_RS15530 | 409477..409890 | + | 414 | Protein_424 | hypothetical protein | - |
| HPY15_RS15535 | 410081..410251 | + | 171 | WP_046127315.1 | hypothetical protein | Antitoxin |
| HPY15_RS15540 | 410251..410652 | + | 402 | WP_046126173.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| HPY15_RS15545 | 410792..411127 | + | 336 | WP_019829648.1 | hypothetical protein | - |
| HPY15_RS15550 | 411321..411465 | + | 145 | Protein_428 | DUF3709 domain-containing protein | - |
| HPY15_RS15555 | 412242..412655 | + | 414 | WP_046126172.1 | VOC family protein | - |
| HPY15_RS15560 | 412889..413911 | + | 1023 | WP_046126171.1 | hypothetical protein | - |
| HPY15_RS15565 | 413952..414434 | + | 483 | WP_001900268.1 | hypothetical protein | - |
| HPY15_RS15570 | 414644..414898 | + | 255 | WP_001223794.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| HPY15_RS15575 | 414891..415154 | + | 264 | WP_000098716.1 | Txe/YoeB family addiction module toxin | - |
| HPY15_RS15580 | 415234..415341 | + | 108 | WP_080341671.1 | acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 296008..431802 | 135794 | |
| - | inside | Integron | - | - | 382712..427017 | 44305 | |
| - | flank | IS/Tn | - | - | 408477..409397 | 920 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14656.80 Da Isoelectric Point: 4.0585
>T157911 WP_046126173.1 NZ_CP053801:410251-410652 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENYLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENYLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
Download Length: 402 bp
>T157911 NZ_CP069508:5815-6102 [Acinetobacter pittii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCACGATGTCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCGTTGAGGATCTCAATCCAAGACAGACATACCGATGGCGAAGAACGTTGGCAGACCATTGGGA
AAGTAAAAGGCGTACTAATGCTCTTAGTAGCTCACACCATCTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGACAAGTAACTAAAGCAGAGCGAGATAAATATGAGCATGGTTAA
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCACGATGTCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCGTTGAGGATCTCAATCCAAGACAGACATACCGATGGCGAAGAACGTTGGCAGACCATTGGGA
AAGTAAAAGGCGTACTAATGCTCTTAGTAGCTCACACCATCTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGACAAGTAACTAAAGCAGAGCGAGATAAATATGAGCATGGTTAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6317.38 Da Isoelectric Point: 10.7274
>AT157911 WP_046127315.1 NZ_CP053801:410081-410251 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDTGRQIVKSETKLALRTHQKTFTKLADM
MNRKVEAYGVDAVERPKIKASKKLDLTGDTGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 171 bp
>AT157911 NZ_CP069508:6089-6403 [Acinetobacter pittii]
ATGAGCATGGTTAAATACTCACGCAAAGAACTGAATGAAAAATTCAGCGACAAGCAAGATGCTGAAATTGAACGCTTGCT
TGCTAAGGGAACAGTTTCTGACGATCATCTAGATCTATCAGATATGCCTGAAATTACCGACTGGAGTAATGCTGTACGCC
ACAATCAATTCTATCGTCCAGTGAAGCAACAAACATCTATTCGTTTAGATGCTGACGTACTTGCATGGTTCAAAGCACAA
GGCAAAGGTTATCAGACACGTATGAATGAAATCTTACGGGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
ATGAGCATGGTTAAATACTCACGCAAAGAACTGAATGAAAAATTCAGCGACAAGCAAGATGCTGAAATTGAACGCTTGCT
TGCTAAGGGAACAGTTTCTGACGATCATCTAGATCTATCAGATATGCCTGAAATTACCGACTGGAGTAATGCTGTACGCC
ACAATCAATTCTATCGTCCAGTGAAGCAACAAACATCTATTCGTTTAGATGCTGACGTACTTGCATGGTTCAAAGCACAA
GGCAAAGGTTATCAGACACGTATGAATGAAATCTTACGGGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|