Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 397941..398479 | Replicon | chromosome |
| Accession | NZ_CP053801 | ||
| Organism | Vibrio cholerae strain SO5Y | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | HPY15_RS15420 | Protein ID | WP_000802136.1 |
| Coordinates | 397941..398240 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | HPY15_RS15425 | Protein ID | WP_001107719.1 |
| Coordinates | 398237..398479 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY15_RS15385 | 393236..393757 | + | 522 | WP_080341682.1 | hypothetical protein | - |
| HPY15_RS15390 | 394506..394919 | + | 414 | WP_046126191.1 | VOC family protein | - |
| HPY15_RS15395 | 395105..395341 | - | 237 | WP_046126190.1 | RNA-binding protein | - |
| HPY15_RS15400 | 395514..395990 | + | 477 | WP_080341680.1 | hypothetical protein | - |
| HPY15_RS15405 | 396181..396438 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY15_RS15410 | 396426..396728 | + | 303 | WP_046126188.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY15_RS15415 | 396904..397818 | + | 915 | WP_046126187.1 | hypothetical protein | - |
| HPY15_RS15420 | 397941..398240 | - | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY15_RS15425 | 398237..398479 | - | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| HPY15_RS15430 | 398847..399167 | + | 321 | Protein_404 | DUF645 family protein | - |
| HPY15_RS15435 | 399234..399572 | + | 339 | WP_046127316.1 | hypothetical protein | - |
| HPY15_RS15440 | 399738..400124 | + | 387 | WP_001015864.1 | NUDIX hydrolase | - |
| HPY15_RS15445 | 400349..400633 | + | 285 | WP_046126186.1 | HEAT repeat domain-containing protein | - |
| HPY15_RS15450 | 400769..401086 | - | 318 | WP_046126185.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY15_RS15455 | 401105..401347 | - | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY15_RS15460 | 401739..401918 | + | 180 | WP_162484547.1 | DUF645 family protein | - |
| HPY15_RS15465 | 402278..402454 | + | 177 | Protein_411 | DUF645 family protein | - |
| HPY15_RS15470 | 402670..403047 | + | 378 | WP_046126182.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 296008..431802 | 135794 | |
| - | inside | Integron | - | - | 382712..427017 | 44305 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T157909 WP_000802136.1 NZ_CP053801:c398240-397941 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T157909 NZ_CP069506:c92492-92199 [Acinetobacter pittii]
ATGACTTATAAGCTTTTACGTAATAAGGACTTCACAGCTGAATGGGAAAAGCTTCCTAGTGCTATAAGAGATCAATTTAA
GAAGAAACTCGCCAAGGTCATAGAGCAGCCACATATTCCCAAGAATATGCTTAGAGGTGATCTCACGGGATGTTATAAAA
TTAAATTACTAAAGACTGGAGTTCGACTGGTCTATCAAGTCAAAGATGATCAGGTAGTTATCTTGCTCATCACCGTTGGG
AAACGAGCTGACAGCATAGTTTATGACGAAGCAAAAAAACGCATTAAAGACTAA
ATGACTTATAAGCTTTTACGTAATAAGGACTTCACAGCTGAATGGGAAAAGCTTCCTAGTGCTATAAGAGATCAATTTAA
GAAGAAACTCGCCAAGGTCATAGAGCAGCCACATATTCCCAAGAATATGCTTAGAGGTGATCTCACGGGATGTTATAAAA
TTAAATTACTAAAGACTGGAGTTCGACTGGTCTATCAAGTCAAAGATGATCAGGTAGTTATCTTGCTCATCACCGTTGGG
AAACGAGCTGACAGCATAGTTTATGACGAAGCAAAAAAACGCATTAAAGACTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT157909 WP_001107719.1 NZ_CP053801:c398479-398237 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT157909 NZ_CP069506:c92727-92482 [Acinetobacter pittii]
ATGGCTACTGTTAACTTCAGGGTTGATGAAGCCCTTAAAGAAAAATCTTATTCAGTTCTTAGAGAACAAGGTATTGCACC
TACTGAGTTTTTTACAAATGTCCTTGAATACATTGCAGCGACTGGGAAACTCCCTGTACAAAAAGCTTTACTCTCAGAAG
AGGATACCGAGCTATTAGCGATTGTTCGTAAACGTATGAATGATCCTAAAGAAATGTTCGAGGAAATTACTTTAGATGAC
TTATAA
ATGGCTACTGTTAACTTCAGGGTTGATGAAGCCCTTAAAGAAAAATCTTATTCAGTTCTTAGAGAACAAGGTATTGCACC
TACTGAGTTTTTTACAAATGTCCTTGAATACATTGCAGCGACTGGGAAACTCCCTGTACAAAAAGCTTTACTCTCAGAAG
AGGATACCGAGCTATTAGCGATTGTTCGTAAACGTATGAATGATCCTAAAGAAATGTTCGAGGAAATTACTTTAGATGAC
TTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7R5A |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7R5A | |
| PDB | 7B22 | |
| AlphaFold DB | A0A151JFU4 |