Detailed information of TA system TA157908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 396181..396728
• Replicon: chromosome
• Accession: NZ_CP053801
• Organism: Vibrio cholerae strain SO5Y

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY15_RS15410
• Protein ID: WP_046126188.1
• Coordinates: 396426..396728 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: HPY15_RS15405
• Protein ID: WP_000861987.1
• Coordinates: 396181..396438 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY15_RS15375	391469..392077	+	609	WP_046126193.1	hypothetical protein	-
HPY15_RS15380	392685..393080	+	396	WP_032473749.1	DUF3465 domain-containing protein	-
HPY15_RS15385	393236..393757	+	522	WP_080341682.1	hypothetical protein	-
HPY15_RS15390	394506..394919	+	414	WP_046126191.1	VOC family protein	-
HPY15_RS15395	395105..395341	-	237	WP_046126190.1	RNA-binding protein	-
HPY15_RS15400	395514..395990	+	477	WP_080341680.1	hypothetical protein	-
HPY15_RS15405	396181..396438	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY15_RS15410	396426..396728	+	303	WP_046126188.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY15_RS15415	396904..397818	+	915	WP_046126187.1	hypothetical protein	-
HPY15_RS15420	397941..398240	-	300	WP_000802136.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY15_RS15425	398237..398479	-	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	-
HPY15_RS15430	398847..399167	+	321	Protein_404	DUF645 family protein	-
HPY15_RS15435	399234..399572	+	339	WP_046127316.1	hypothetical protein	-
HPY15_RS15440	399738..400124	+	387	WP_001015864.1	NUDIX hydrolase	-
HPY15_RS15445	400349..400633	+	285	WP_046126186.1	HEAT repeat domain-containing protein	-
HPY15_RS15450	400769..401086	-	318	WP_046126185.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY15_RS15455	401105..401347	-	243	WP_000557291.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	296008..431802	135794
	-	inside	Integron	-	-	382712..427017	44305

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11709.61 Da
• Isoelectric Point: 5.1972

>T157908 WP_046126188.1 NZ_CP053801:396426-396728 [Vibrio cholerae]
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T157908 NZ_CP069506:c90881-90573 [Acinetobacter pittii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGACGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT157908 WP_000861987.1 NZ_CP053801:396181-396438 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT157908 NZ_CP069506:c90532-90230 [Acinetobacter pittii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTGGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGATTCAATGTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A1T4SLM9