Detailed information of TA system TA157907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 390754..391252
• Replicon: chromosome
• Accession: NZ_CP053801
• Organism: Vibrio cholerae strain SO5Y

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK7
• Locus tag: HPY15_RS15365
• Protein ID: WP_000589156.1
• Coordinates: 390754..391020 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK6
• Locus tag: HPY15_RS15370
• Protein ID: WP_000643598.1
• Coordinates: 391007..391252 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY15_RS15325	385995..386309	+	315	WP_000071008.1	DNA-binding transcriptional regulator	-
HPY15_RS15330	386603..386730	+	128	Protein_384	DUF645 family protein	-
HPY15_RS15335	386746..386784	+	39	WP_108244118.1	hypothetical protein	-
HPY15_RS15340	387287..387424	+	138	WP_000757220.1	YHYH domain-containing protein	-
HPY15_RS15345	387616..387978	+	363	WP_162484548.1	DUF4144 domain-containing protein	-
HPY15_RS15350	388141..388488	+	348	WP_000933405.1	hypothetical protein	-
HPY15_RS15355	388620..389108	+	489	WP_175235995.1	GNAT family N-acetyltransferase	-
HPY15_RS15360	389131..390090	-	960	WP_001898459.1	IS30 family transposase	-
HPY15_RS15365	390754..391020	+	267	WP_000589156.1	BrnT family toxin	Toxin
HPY15_RS15370	391007..391252	+	246	WP_000643598.1	hypothetical protein	Antitoxin
HPY15_RS15375	391469..392077	+	609	WP_046126193.1	hypothetical protein	-
HPY15_RS15380	392685..393080	+	396	WP_032473749.1	DUF3465 domain-containing protein	-
HPY15_RS15385	393236..393757	+	522	WP_080341682.1	hypothetical protein	-
HPY15_RS15390	394506..394919	+	414	WP_046126191.1	VOC family protein	-
HPY15_RS15395	395105..395341	-	237	WP_046126190.1	RNA-binding protein	-
HPY15_RS15400	395514..395990	+	477	WP_080341680.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	296008..431802	135794
	-	inside	Integron	-	-	382712..427017	44305

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10092.34 Da
• Isoelectric Point: 7.3171

>T157907 WP_000589156.1 NZ_CP053801:390754-391020 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Nucleotide

• Length: 267 bp

>T157907 NZ_CP069506:c57431-57102 [Acinetobacter pittii]
ATGTATACAATTGAATATTACAGCGAAGACGTTCAGGATGAGATTCTTACATTACCTGATGGTCTTTTGGCTCGATATTT
TAACTTAACTGACCGTATGGTGATTTACGGCGCAAACTTAGGAGAACCTCACACATTACCAATGAGTAAAGGACTATTTG
AGTTGCGCTTAAAATCTCAAGAAGGTATTGCTCGTGTTATGTATTGCACACTAGTCGGTAAACGCATTGTAATGCTCCAT
AGTTTTGTTAAGAAAACCCAAAAAACACCTAAGCAAGATCTAAACCTAGCACTTGACCGCATGAAAGAGGTGAAAAATGC
GAACACATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9478.77 Da
• Isoelectric Point: 6.4832

>AT157907 WP_000643598.1 NZ_CP053801:391007-391252 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Nucleotide

• Length: 246 bp

>AT157907 NZ_CP069506:c57115-56828 [Acinetobacter pittii]
ATGCGAACACATGAAGAAATGAAAGCACTTGCATTATCTCGTTCAGCAGTGCGTACCGAATACGAACGAATTGAACGTGA
AGAAATGCCCCTGCTCGATATGGTACTTACTGCACGTCGAGATGCAGGTCTATCCCAAGCGCAAATCGCGGAACGCATGG
GAACAAGTGTACCTGCCGTTTCACGGCTAGAAAAAGCATTGATCACAGGCAAACCATCACCATCTATTGCCACATTGCAA
AAATATGCTGCGGCAATTGGTAAACATGTTGAAGTGCGTTTTGTCTAA

Structures

Toxin

• AlphaFold DB: A0A271VMP7

Antitoxin

• AlphaFold DB: A0A271VME2