Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 375187..375727 Replicon chromosome
Accession NZ_CP053801
Organism Vibrio cholerae strain SO5Y

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag HPY15_RS15230 Protein ID WP_000277238.1
Coordinates 375458..375727 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag HPY15_RS15225 Protein ID WP_001258569.1
Coordinates 375187..375465 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY15_RS15185 370413..370937 - 525 WP_142741359.1 hypothetical protein -
HPY15_RS15190 371085..371822 - 738 WP_046126202.1 hypothetical protein -
HPY15_RS15195 371965..372313 - 349 Protein_357 GrpB family protein -
HPY15_RS15200 372576..373031 - 456 WP_000432865.1 hypothetical protein -
HPY15_RS15205 373182..373703 - 522 WP_000921691.1 DUF2442 domain-containing protein -
HPY15_RS15210 373697..373966 - 270 WP_001114075.1 DUF4160 domain-containing protein -
HPY15_RS15215 374218..374313 - 96 WP_001907607.1 DUF645 family protein -
HPY15_RS15220 374556..374666 - 111 WP_086017781.1 DUF3265 domain-containing protein -
HPY15_RS15225 375187..375465 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY15_RS15230 375458..375727 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
HPY15_RS15235 376323..376748 - 426 WP_052724878.1 hypothetical protein -
HPY15_RS15240 376895..377593 - 699 WP_046126203.1 HAD family phosphatase -
HPY15_RS15245 377684..378241 - 558 WP_046126204.1 GNAT family N-acetyltransferase -
HPY15_RS15250 378238..378336 - 99 WP_142741450.1 acetyltransferase -
HPY15_RS15255 378453..378701 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY15_RS15260 378691..378981 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY15_RS15265 378999..379109 - 111 WP_082798255.1 DUF3265 domain-containing protein -
HPY15_RS15270 379106..379423 - 318 WP_001232701.1 HigA family addiction module antidote protein -
HPY15_RS15275 379434..379721 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY15_RS15280 380073..380281 - 209 Protein_374 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 296008..431802 135794
- inside Integron - - 297172..370435 73263
- flank IS/Tn - - 369515..370435 920
- inside Integron - - 370413..382391 11978


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T157903 WP_000277238.1 NZ_CP053801:375458-375727 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T157903 NZ_CP069502:c24882-24724 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT157903 WP_001258569.1 NZ_CP053801:375187-375465 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT157903 NZ_CP069502:c25150-24926 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References