157902

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 373182..373966 Replicon chromosome
Accession NZ_CP053801
Organism Vibrio cholerae strain SO5Y

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag HPY15_RS15210 Protein ID WP_001114075.1
Coordinates 373697..373966 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag HPY15_RS15205 Protein ID WP_000921691.1
Coordinates 373182..373703 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY15_RS15175 368217..369176 - 960 WP_001898459.1 IS30 family transposase -
HPY15_RS15180 369515..370435 + 921 WP_001896359.1 IS5-like element ISVch8 family transposase -
HPY15_RS15185 370413..370937 - 525 WP_142741359.1 hypothetical protein -
HPY15_RS15190 371085..371822 - 738 WP_046126202.1 hypothetical protein -
HPY15_RS15195 371965..372313 - 349 Protein_357 GrpB family protein -
HPY15_RS15200 372576..373031 - 456 WP_000432865.1 hypothetical protein -
HPY15_RS15205 373182..373703 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
HPY15_RS15210 373697..373966 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
HPY15_RS15215 374218..374313 - 96 WP_001907607.1 DUF645 family protein -
HPY15_RS15220 374556..374666 - 111 WP_086017781.1 DUF3265 domain-containing protein -
HPY15_RS15225 375187..375465 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HPY15_RS15230 375458..375727 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
HPY15_RS15235 376323..376748 - 426 WP_052724878.1 hypothetical protein -
HPY15_RS15240 376895..377593 - 699 WP_046126203.1 HAD family phosphatase -
HPY15_RS15245 377684..378241 - 558 WP_046126204.1 GNAT family N-acetyltransferase -
HPY15_RS15250 378238..378336 - 99 WP_142741450.1 acetyltransferase -
HPY15_RS15255 378453..378701 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 296008..431802 135794
- inside Integron - - 297172..370435 73263
- flank IS/Tn - - 369515..370435 920
- inside Integron - - 370413..382391 11978


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T157902 WP_001114075.1 NZ_CP053801:c373966-373697 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T157902 NZ_CP069501:c4607854-4607669 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT157902 WP_000921691.1 NZ_CP053801:c373703-373182 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT157902 NZ_CP069501:c4607652-4607242 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGG
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References