Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 328403..328974 Replicon chromosome
Accession NZ_CP053801
Organism Vibrio cholerae strain SO5Y

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HPY15_RS14880 Protein ID WP_046126173.1
Coordinates 328573..328974 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A544N0N8
Locus tag HPY15_RS14875 Protein ID WP_046127315.1
Coordinates 328403..328573 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY15_RS14830 323811..324164 + 354 WP_050559285.1 DUF4144 domain-containing protein -
HPY15_RS14835 324425..324685 + 261 WP_175236095.1 DUF3709 domain-containing protein -
HPY15_RS14840 325110..325237 + 128 Protein_286 DUF645 family protein -
HPY15_RS14845 325253..325291 + 39 WP_108244118.1 hypothetical protein -
HPY15_RS14850 325486..326022 + 537 WP_046126196.1 nucleotidyltransferase family protein -
HPY15_RS14855 326235..326501 + 267 WP_095466608.1 hypothetical protein -
HPY15_RS14860 326814..326996 + 183 WP_032473240.1 DUF645 family protein -
HPY15_RS14865 327198..327584 + 387 WP_175235979.1 MmcQ/YjbR family DNA-binding protein -
HPY15_RS14870 327812..328090 + 279 WP_032469024.1 DUF3709 domain-containing protein -
HPY15_RS14875 328403..328573 + 171 WP_046127315.1 hypothetical protein Antitoxin
HPY15_RS14880 328573..328974 + 402 WP_046126173.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HPY15_RS14885 329114..330004 + 891 WP_094393050.1 hypothetical protein -
HPY15_RS14890 330746..331066 + 321 Protein_296 DUF645 family protein -
HPY15_RS14895 331284..331462 + 179 Protein_297 DUF645 family protein -
HPY15_RS14900 331665..331946 + 282 WP_142741056.1 hypothetical protein -
HPY15_RS14905 332117..332512 + 396 WP_046126178.1 DUF3465 domain-containing protein -
HPY15_RS14910 332809..333027 + 219 Protein_300 DUF3709 domain-containing protein -
HPY15_RS14915 333300..333935 + 636 WP_000691786.1 DUF2807 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 296008..431802 135794
- inside Integron - - 297172..370435 73263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(9-102)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14656.80 Da        Isoelectric Point: 4.0585

>T157901 WP_046126173.1 NZ_CP053801:328573-328974 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENYLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T157901 NZ_CP069501:c4552487-4552380 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6317.38 Da        Isoelectric Point: 10.7274

>AT157901 WP_046127315.1 NZ_CP053801:328403-328573 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDTGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT157901 NZ_CP069501:4552535-4552601 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A544N0N8

References