Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 314130..314708 Replicon chromosome
Accession NZ_CP053801
Organism Vibrio cholerae strain SO5Y

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag HPY15_RS14750 Protein ID WP_001180243.1
Coordinates 314130..314447 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HPY15_RS14755 Protein ID WP_001961623.1
Coordinates 314466..314708 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY15_RS14720 309256..309381 + 126 WP_175236093.1 DUF3265 domain-containing protein -
HPY15_RS14725 309410..311233 + 1824 WP_175235966.1 hypothetical protein -
HPY15_RS14730 311372..311869 + 498 WP_055030562.1 DUF2867 domain-containing protein -
HPY15_RS14735 312400..312933 + 534 WP_000679873.1 GNAT family N-acetyltransferase -
HPY15_RS14740 313074..313460 + 387 WP_089069923.1 MmcQ/YjbR family DNA-binding protein -
HPY15_RS14745 313755..313937 + 183 WP_000947519.1 DUF645 family protein -
HPY15_RS14750 314130..314447 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY15_RS14755 314466..314708 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY15_RS14760 314955..315731 + 777 WP_175235968.1 hypothetical protein -
HPY15_RS14765 315897..316310 + 414 WP_142738042.1 GNAT family N-acetyltransferase -
HPY15_RS14770 316448..316765 - 318 WP_000077272.1 CcdB family protein -
HPY15_RS14775 316765..317010 - 246 WP_001260801.1 type II toxin-antitoxin system CcdA family antitoxin -
HPY15_RS14780 317208..317570 + 363 WP_175235970.1 hypothetical protein -
HPY15_RS14785 317713..318471 + 759 WP_175235971.1 restriction endonuclease -
HPY15_RS14790 318824..318919 + 96 WP_001907607.1 DUF645 family protein -
HPY15_RS14795 319129..319584 + 456 WP_000432865.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 296008..431802 135794
- inside Integron - - 297172..370435 73263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T157900 WP_001180243.1 NZ_CP053801:c314447-314130 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T157900 NZ_CP069501:c4552004-4551897 [Escherichia coli]
ATGACGCTCGCAGCGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8931.22 Da        Isoelectric Point: 5.6630

>AT157900 WP_001961623.1 NZ_CP053801:c314708-314466 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL

Download         Length: 243 bp

>AT157900 NZ_CP069501:4552052-4552118 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure

References