Detailed information of TA system TA157899

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 304869..305428
• Replicon: chromosome
• Accession: NZ_CP053801
• Organism: Vibrio cholerae strain SO5Y

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY15_RS14685
• Protein ID: WP_142741541.1
• Coordinates: 304869..305147 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9L991
• Locus tag: HPY15_RS14690
• Protein ID: WP_000381183.1
• Coordinates: 305144..305428 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY15_RS14640	300087..300233	+	147	WP_145474494.1	DUF3265 domain-containing protein	-
HPY15_RS14645	300350..301294	+	945	WP_175235964.1	Abi family protein	-
HPY15_RS14650	301685..301774	+	90	Protein_248	DUF645 family protein	-
HPY15_RS14655	302130..302251	+	122	Protein_249	DUF645 family protein	-
HPY15_RS14660	302270..302308	+	39	WP_082798268.1	hypothetical protein	-
HPY15_RS14665	302506..303432	+	927	WP_148502345.1	PD-(D/E)XK nuclease superfamily protein	-
HPY15_RS14670	303728..303910	+	183	WP_046126209.1	DUF645 family protein	-
HPY15_RS14675	304109..304720	+	612	WP_095430815.1	hypothetical protein	-
HPY15_RS14680	304714..304839	+	126	WP_142741543.1	DUF3265 domain-containing protein	-
HPY15_RS14685	304869..305147	-	279	WP_142741541.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY15_RS14690	305144..305428	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HPY15_RS14695	305626..306030	+	405	WP_142741542.1	DUF1801 domain-containing protein	-
HPY15_RS14700	306179..306715	+	537	WP_046126196.1	nucleotidyltransferase family protein	-
HPY15_RS14705	306984..307220	+	237	WP_080341691.1	DUF3709 domain-containing protein	-
HPY15_RS14710	307484..307972	+	489	WP_046126199.1	GNAT family N-acetyltransferase	-
HPY15_RS14715	308621..309268	+	648	WP_000376693.1	GIY-YIG nuclease family protein	-
HPY15_RS14720	309256..309381	+	126	WP_175236093.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	296008..431802	135794
	-	inside	Integron	-	-	297172..370435	73263

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10896.60 Da
• Isoelectric Point: 4.5482

>T157899 WP_142741541.1 NZ_CP053801:c305147-304869 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDDSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T157899 NZ_CP069501:c4551520-4551413 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.25 Da
• Isoelectric Point: 8.0775

>AT157899 WP_000381183.1 NZ_CP053801:c305428-305144 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT157899 NZ_CP069501:4551568-4551634 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: A0A067BL33