Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2198133..2199955 Replicon chromosome
Accession NZ_CP053800
Organism Vibrio cholerae strain SO5Y

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HPY15_RS09940 Protein ID WP_175235782.1
Coordinates 2198133..2199494 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HPY15_RS09945 Protein ID WP_175235784.1
Coordinates 2199491..2199955 (+) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY15_RS09905 2193242..2193931 + 690 WP_046126478.1 hypothetical protein -
HPY15_RS09910 2194010..2194668 - 659 Protein_1920 inovirus Gp2 family protein -
HPY15_RS09915 2195121..2196230 + 1110 WP_175235780.1 hypothetical protein -
HPY15_RS09920 2196259..2196459 - 201 WP_046126475.1 AlpA family transcriptional regulator -
HPY15_RS09925 2196551..2196840 - 290 Protein_1923 type II toxin-antitoxin system RelE/ParE family toxin -
HPY15_RS09930 2196830..2197078 - 249 WP_046126474.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY15_RS09935 2197187..2197486 - 300 WP_046127337.1 helix-turn-helix transcriptional regulator -
HPY15_RS09940 2198133..2199494 + 1362 WP_175235782.1 type II toxin-antitoxin system HipA family toxin Toxin
HPY15_RS09945 2199491..2199955 + 465 WP_175235784.1 helix-turn-helix domain-containing protein Antitoxin
HPY15_RS09950 2200261..2203533 - 3273 WP_175235786.1 HsdR family type I site-specific deoxyribonuclease -
HPY15_RS09955 2203603..2204949 - 1347 WP_114811716.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(79-137)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51317.19 Da        Isoelectric Point: 5.0545

>T157898 WP_175235782.1 NZ_CP053800:2198133-2199494 [Vibrio cholerae]
MEELTVQAFIRGEWRDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFFFDDKGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRALIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T157898 NZ_CP069501:c4551037-4550930 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCCCCGGTCATTGCTGGCATTTTTGCCAGTCTGAT
CGTGAACTCGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 16949.46 Da        Isoelectric Point: 10.7084

>AT157898 WP_175235784.1 NZ_CP053800:2199491-2199955 [Vibrio cholerae]
MKPSSKESVQDTVARLRANRNQQQPKVGKNATHSIKEQTLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQGQ
ALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 465 bp

>AT157898 NZ_CP069501:4551094-4551149 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References