Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-YafN |
Location | 430749..431277 | Replicon | chromosome |
Accession | NZ_CP053799 | ||
Organism | Vibrio cholerae strain SL5Y |
Toxin (Protein)
Gene name | relE | Uniprot ID | H9L4R3 |
Locus tag | HPY14_RS15790 | Protein ID | WP_000221352.1 |
Coordinates | 430749..431039 (-) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | H9L4T4 |
Locus tag | HPY14_RS15795 | Protein ID | WP_000213183.1 |
Coordinates | 431029..431277 (-) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HPY14_RS15740 | 425990..426274 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
HPY14_RS15745 | 426516..426839 | + | 324 | WP_080299109.1 | DUF3709 domain-containing protein | - |
HPY14_RS15750 | 427114..427611 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
HPY14_RS15755 | 427608..427880 | - | 273 | WP_001915058.1 | DUF1778 domain-containing protein | - |
HPY14_RS15760 | 428126..428413 | + | 288 | WP_094392995.1 | SHOCT domain-containing protein | - |
HPY14_RS15765 | 428481..428714 | + | 234 | WP_094392996.1 | hypothetical protein | - |
HPY14_RS15770 | 428717..428833 | + | 117 | WP_094392999.1 | DUF3265 domain-containing protein | - |
HPY14_RS15775 | 428843..429358 | + | 516 | WP_000090011.1 | hypothetical protein | - |
HPY14_RS15780 | 429478..429966 | + | 489 | WP_057561119.1 | dual specificity protein phosphatase family protein | - |
HPY14_RS15785 | 430113..430622 | + | 510 | WP_094392997.1 | GNAT family N-acetyltransferase | - |
HPY14_RS15790 | 430749..431039 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HPY14_RS15795 | 431029..431277 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
HPY14_RS15800 | 431684..431818 | + | 135 | WP_019830500.1 | DUF645 family protein | - |
HPY14_RS15805 | 432181..432405 | + | 225 | WP_094393000.1 | hypothetical protein | - |
HPY14_RS15810 | 432693..432824 | + | 132 | WP_162298941.1 | DUF3709 domain-containing protein | - |
HPY14_RS15815 | 432837..432911 | + | 75 | WP_108244119.1 | hypothetical protein | - |
HPY14_RS15820 | 433332..433463 | + | 132 | WP_162298941.1 | DUF3709 domain-containing protein | - |
HPY14_RS15825 | 433476..433550 | + | 75 | WP_108244120.1 | hypothetical protein | - |
HPY14_RS15830 | 433819..434244 | + | 426 | WP_094393063.1 | GNAT family N-acetyltransferase | - |
HPY14_RS15835 | 434382..434858 | + | 477 | Protein_479 | GNAT family N-acetyltransferase | - |
HPY14_RS15840 | 434881..435840 | - | 960 | WP_094393086.1 | IS30 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 307775..455729 | 147954 | |
- | inside | Integron | - | - | 308939..456912 | 147973 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11247.23 Da Isoelectric Point: 10.4678
>T157896 WP_000221352.1 NZ_CP053799:c431039-430749 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T157896 NZ_CP069501:4140275-4140739 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8937.28 Da Isoelectric Point: 4.1079
>AT157896 WP_000213183.1 NZ_CP053799:c431277-431029 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT157896 NZ_CP069501:4139940-4140275 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | H9L4R3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A366A3W8 |