157896

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 430749..431277 Replicon chromosome
Accession NZ_CP053799
Organism Vibrio cholerae strain SL5Y

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag HPY14_RS15790 Protein ID WP_000221352.1
Coordinates 430749..431039 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag HPY14_RS15795 Protein ID WP_000213183.1
Coordinates 431029..431277 (-) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY14_RS15740 425990..426274 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HPY14_RS15745 426516..426839 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY14_RS15750 427114..427611 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
HPY14_RS15755 427608..427880 - 273 WP_001915058.1 DUF1778 domain-containing protein -
HPY14_RS15760 428126..428413 + 288 WP_094392995.1 SHOCT domain-containing protein -
HPY14_RS15765 428481..428714 + 234 WP_094392996.1 hypothetical protein -
HPY14_RS15770 428717..428833 + 117 WP_094392999.1 DUF3265 domain-containing protein -
HPY14_RS15775 428843..429358 + 516 WP_000090011.1 hypothetical protein -
HPY14_RS15780 429478..429966 + 489 WP_057561119.1 dual specificity protein phosphatase family protein -
HPY14_RS15785 430113..430622 + 510 WP_094392997.1 GNAT family N-acetyltransferase -
HPY14_RS15790 430749..431039 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY14_RS15795 431029..431277 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY14_RS15800 431684..431818 + 135 WP_019830500.1 DUF645 family protein -
HPY14_RS15805 432181..432405 + 225 WP_094393000.1 hypothetical protein -
HPY14_RS15810 432693..432824 + 132 WP_162298941.1 DUF3709 domain-containing protein -
HPY14_RS15815 432837..432911 + 75 WP_108244119.1 hypothetical protein -
HPY14_RS15820 433332..433463 + 132 WP_162298941.1 DUF3709 domain-containing protein -
HPY14_RS15825 433476..433550 + 75 WP_108244120.1 hypothetical protein -
HPY14_RS15830 433819..434244 + 426 WP_094393063.1 GNAT family N-acetyltransferase -
HPY14_RS15835 434382..434858 + 477 Protein_479 GNAT family N-acetyltransferase -
HPY14_RS15840 434881..435840 - 960 WP_094393086.1 IS30 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 307775..455729 147954
- inside Integron - - 308939..456912 147973


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-86)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T157896 WP_000221352.1 NZ_CP053799:c431039-430749 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T157896 NZ_CP069501:4140275-4140739 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT157896 WP_000213183.1 NZ_CP053799:c431277-431029 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT157896 NZ_CP069501:4139940-4140275 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB H9L4R3


Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References