Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 427114..427880 | Replicon | chromosome |
| Accession | NZ_CP053799 | ||
| Organism | Vibrio cholerae strain SL5Y | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9K2P7 |
| Locus tag | HPY14_RS15750 | Protein ID | WP_000982260.1 |
| Coordinates | 427114..427611 (-) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | HPY14_RS15755 | Protein ID | WP_001915058.1 |
| Coordinates | 427608..427880 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY14_RS15705 | 422291..422410 | + | 120 | WP_162843095.1 | acetyltransferase | - |
| HPY14_RS15710 | 422394..422630 | - | 237 | WP_000772130.1 | RNA-binding protein | - |
| HPY14_RS15715 | 423646..423903 | + | 258 | WP_055031549.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY14_RS15720 | 423891..424193 | + | 303 | WP_095486992.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY14_RS15725 | 424359..425075 | + | 717 | WP_094393090.1 | hypothetical protein | - |
| HPY14_RS15730 | 425200..425562 | + | 363 | WP_175234023.1 | hypothetical protein | - |
| HPY14_RS15735 | 425715..425993 | - | 279 | WP_000578475.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| HPY14_RS15740 | 425990..426274 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY14_RS15745 | 426516..426839 | + | 324 | WP_080299109.1 | DUF3709 domain-containing protein | - |
| HPY14_RS15750 | 427114..427611 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | Toxin |
| HPY14_RS15755 | 427608..427880 | - | 273 | WP_001915058.1 | DUF1778 domain-containing protein | Antitoxin |
| HPY14_RS15760 | 428126..428413 | + | 288 | WP_094392995.1 | SHOCT domain-containing protein | - |
| HPY14_RS15765 | 428481..428714 | + | 234 | WP_094392996.1 | hypothetical protein | - |
| HPY14_RS15770 | 428717..428833 | + | 117 | WP_094392999.1 | DUF3265 domain-containing protein | - |
| HPY14_RS15775 | 428843..429358 | + | 516 | WP_000090011.1 | hypothetical protein | - |
| HPY14_RS15780 | 429478..429966 | + | 489 | WP_057561119.1 | dual specificity protein phosphatase family protein | - |
| HPY14_RS15785 | 430113..430622 | + | 510 | WP_094392997.1 | GNAT family N-acetyltransferase | - |
| HPY14_RS15790 | 430749..431039 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY14_RS15795 | 431029..431277 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY14_RS15800 | 431684..431818 | + | 135 | WP_019830500.1 | DUF645 family protein | - |
| HPY14_RS15805 | 432181..432405 | + | 225 | WP_094393000.1 | hypothetical protein | - |
| HPY14_RS15810 | 432693..432824 | + | 132 | WP_162298941.1 | DUF3709 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 307775..455729 | 147954 | |
| - | inside | Integron | - | - | 308939..456912 | 147973 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18527.18 Da Isoelectric Point: 8.7753
>T157895 WP_000982260.1 NZ_CP053799:c427611-427114 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
>T157895 NZ_CP069501:c3837206-3836799 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTAATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTACGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGTGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTAATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTACGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGTGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 9655.16 Da Isoelectric Point: 6.2988
>AT157895 WP_001915058.1 NZ_CP053799:c427880-427608 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT157895 NZ_CP069501:c3837453-3837187 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|