Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 425715..426274 Replicon chromosome
Accession NZ_CP053799
Organism Vibrio cholerae strain SL5Y

Toxin (Protein)


Gene name relE Uniprot ID A0A0Q0N9E9
Locus tag HPY14_RS15735 Protein ID WP_000578475.1
Coordinates 425715..425993 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag HPY14_RS15740 Protein ID WP_000381183.1
Coordinates 425990..426274 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY14_RS15700 421817..422206 + 390 WP_000491261.1 VOC family protein -
HPY14_RS15705 422291..422410 + 120 WP_162843095.1 acetyltransferase -
HPY14_RS15710 422394..422630 - 237 WP_000772130.1 RNA-binding protein -
HPY14_RS15715 423646..423903 + 258 WP_055031549.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY14_RS15720 423891..424193 + 303 WP_095486992.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY14_RS15725 424359..425075 + 717 WP_094393090.1 hypothetical protein -
HPY14_RS15730 425200..425562 + 363 WP_175234023.1 hypothetical protein -
HPY14_RS15735 425715..425993 - 279 WP_000578475.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPY14_RS15740 425990..426274 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY14_RS15745 426516..426839 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY14_RS15750 427114..427611 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
HPY14_RS15755 427608..427880 - 273 WP_001915058.1 DUF1778 domain-containing protein -
HPY14_RS15760 428126..428413 + 288 WP_094392995.1 SHOCT domain-containing protein -
HPY14_RS15765 428481..428714 + 234 WP_094392996.1 hypothetical protein -
HPY14_RS15770 428717..428833 + 117 WP_094392999.1 DUF3265 domain-containing protein -
HPY14_RS15775 428843..429358 + 516 WP_000090011.1 hypothetical protein -
HPY14_RS15780 429478..429966 + 489 WP_057561119.1 dual specificity protein phosphatase family protein -
HPY14_RS15785 430113..430622 + 510 WP_094392997.1 GNAT family N-acetyltransferase -
HPY14_RS15790 430749..431039 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 307775..455729 147954
- inside Integron - - 308939..456912 147973


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10824.53 Da        Isoelectric Point: 4.6794

>T157894 WP_000578475.1 NZ_CP053799:c425993-425715 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDEVIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T157894 NZ_CP069501:c3713920-3713585 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTCAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTTGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT157894 WP_000381183.1 NZ_CP053799:c426274-425990 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT157894 NZ_CP069501:c3714168-3713920 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCTCCTGCAGTGCGGATCCCAGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGGCCTGGTGGATGGCAAATTAATTATTGAGCCAGTACGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAGCGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0N9E9

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References