Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 423646..424193 Replicon chromosome
Accession NZ_CP053799
Organism Vibrio cholerae strain SL5Y

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HPY14_RS15720 Protein ID WP_095486992.1
Coordinates 423891..424193 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HPY14_RS15715 Protein ID WP_055031549.1
Coordinates 423646..423903 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY14_RS15680 418980..419267 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY14_RS15685 419278..419595 + 318 WP_001232701.1 HigA family addiction module antidote protein -
HPY14_RS15690 420152..420265 + 114 Protein_450 DUF645 family protein -
HPY14_RS15695 420483..421613 + 1131 WP_094393023.1 DUF4238 domain-containing protein -
HPY14_RS15700 421817..422206 + 390 WP_000491261.1 VOC family protein -
HPY14_RS15705 422291..422410 + 120 WP_162843095.1 acetyltransferase -
HPY14_RS15710 422394..422630 - 237 WP_000772130.1 RNA-binding protein -
HPY14_RS15715 423646..423903 + 258 WP_055031549.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY14_RS15720 423891..424193 + 303 WP_095486992.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY14_RS15725 424359..425075 + 717 WP_094393090.1 hypothetical protein -
HPY14_RS15730 425200..425562 + 363 WP_175234023.1 hypothetical protein -
HPY14_RS15735 425715..425993 - 279 WP_000578475.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HPY14_RS15740 425990..426274 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HPY14_RS15745 426516..426839 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY14_RS15750 427114..427611 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
HPY14_RS15755 427608..427880 - 273 WP_001915058.1 DUF1778 domain-containing protein -
HPY14_RS15760 428126..428413 + 288 WP_094392995.1 SHOCT domain-containing protein -
HPY14_RS15765 428481..428714 + 234 WP_094392996.1 hypothetical protein -
HPY14_RS15770 428717..428833 + 117 WP_094392999.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 307775..455729 147954
- inside Integron - - 308939..456912 147973


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11771.73 Da        Isoelectric Point: 5.8807

>T157893 WP_095486992.1 NZ_CP053799:423891-424193 [Vibrio cholerae]
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYYDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T157893 NZ_CP069501:2786064-2786558 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9619.14 Da        Isoelectric Point: 7.3176

>AT157893 WP_055031549.1 NZ_CP053799:423646-423903 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDKM
SKWLK

Download         Length: 258 bp

>AT157893 NZ_CP069501:2785774-2786067 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References