Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 388310..388848 | Replicon | chromosome |
| Accession | NZ_CP053799 | ||
| Organism | Vibrio cholerae strain SL5Y | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A0N8UHD2 |
| Locus tag | HPY14_RS15410 | Protein ID | WP_000802131.1 |
| Coordinates | 388310..388609 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A0Q0JMN6 |
| Locus tag | HPY14_RS15415 | Protein ID | WP_002044787.1 |
| Coordinates | 388606..388848 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY14_RS15365 | 383654..383832 | + | 179 | Protein_385 | DUF645 family protein | - |
| HPY14_RS15370 | 384033..384668 | + | 636 | WP_000691786.1 | DUF2807 domain-containing protein | - |
| HPY14_RS15375 | 384980..385159 | + | 180 | WP_094392958.1 | DUF645 family protein | - |
| HPY14_RS15380 | 385362..385931 | + | 570 | WP_057552822.1 | hypothetical protein | - |
| HPY14_RS15385 | 385928..386440 | + | 513 | WP_057552823.1 | hypothetical protein | - |
| HPY14_RS15390 | 386600..386959 | + | 360 | WP_175234021.1 | VOC family protein | - |
| HPY14_RS15395 | 387247..387429 | + | 183 | WP_001933122.1 | DUF645 family protein | - |
| HPY14_RS15400 | 387638..388195 | + | 558 | WP_095488179.1 | 3'-5' exonuclease | - |
| HPY14_RS15405 | 388192..388302 | + | 111 | Protein_393 | DUF3265 domain-containing protein | - |
| HPY14_RS15410 | 388310..388609 | - | 300 | WP_000802131.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY14_RS15415 | 388606..388848 | - | 243 | WP_002044787.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| HPY14_RS15420 | 388896..389027 | + | 132 | WP_080483479.1 | DUF3265 domain-containing protein | - |
| HPY14_RS15425 | 389056..389553 | + | 498 | WP_094392957.1 | DUF2867 domain-containing protein | - |
| HPY14_RS15430 | 389858..390028 | + | 171 | WP_094392956.1 | DUF645 family protein | - |
| HPY14_RS15435 | 390244..390639 | + | 396 | WP_094392955.1 | cell envelope integrity protein TolA | - |
| HPY14_RS15440 | 390922..391113 | + | 192 | WP_094392953.1 | DUF3709 domain-containing protein | - |
| HPY14_RS15445 | 391464..391817 | + | 354 | WP_172626102.1 | nuclear transport factor 2 family protein | - |
| HPY14_RS15450 | 392107..392520 | + | 414 | WP_061036318.1 | hypothetical protein | - |
| HPY14_RS15455 | 392810..392992 | + | 183 | WP_094392952.1 | DUF645 family protein | - |
| HPY14_RS15460 | 393244..393798 | + | 555 | WP_108244021.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 307775..455729 | 147954 | |
| - | inside | Integron | - | - | 308939..456912 | 147973 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11607.26 Da Isoelectric Point: 9.9232
>T157891 WP_000802131.1 NZ_CP053799:c388609-388310 [Vibrio cholerae]
MKPFNLTTAAKTDLRDIALFTQRRWGKEQRNIYLKQFDDSFWLLAENPDIGKSCDEIRDGYRKFPQGSHVIFYQQTGSQQ
IRVVRILHKSMDVNPIFGA
MKPFNLTTAAKTDLRDIALFTQRRWGKEQRNIYLKQFDDSFWLLAENPDIGKSCDEIRDGYRKFPQGSHVIFYQQTGSQQ
IRVVRILHKSMDVNPIFGA
Download Length: 300 bp
>T157891 NZ_CP069501:2375401-2375679 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCAGATATCGATATGCCCGGTTACCGATTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGGATAACGTTCGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCAGATATCGATATGCCCGGTTACCGATTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGGATAACGTTCGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8979.81 Da Isoelectric Point: 4.1677
>AT157891 WP_002044787.1 NZ_CP053799:c388848-388606 [Vibrio cholerae]
MAKNTSITLGEHFDGFITNQIQSGRYGSASEVIRSALRLLENQETKLQTLRQLLVEGEQSGDADYDLDSFINELDSETNR
MAKNTSITLGEHFDGFITNQIQSGRYGSASEVIRSALRLLENQETKLQTLRQLLVEGEQSGDADYDLDSFINELDSETNR
Download Length: 243 bp
>AT157891 NZ_CP069501:2375679-2375963 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCTATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGCCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCTATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGCCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N8UHD2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0JMN6 |