Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 388310..388848 Replicon chromosome
Accession NZ_CP053799
Organism Vibrio cholerae strain SL5Y

Toxin (Protein)


Gene name parE Uniprot ID A0A0N8UHD2
Locus tag HPY14_RS15410 Protein ID WP_000802131.1
Coordinates 388310..388609 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0Q0JMN6
Locus tag HPY14_RS15415 Protein ID WP_002044787.1
Coordinates 388606..388848 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY14_RS15365 383654..383832 + 179 Protein_385 DUF645 family protein -
HPY14_RS15370 384033..384668 + 636 WP_000691786.1 DUF2807 domain-containing protein -
HPY14_RS15375 384980..385159 + 180 WP_094392958.1 DUF645 family protein -
HPY14_RS15380 385362..385931 + 570 WP_057552822.1 hypothetical protein -
HPY14_RS15385 385928..386440 + 513 WP_057552823.1 hypothetical protein -
HPY14_RS15390 386600..386959 + 360 WP_175234021.1 VOC family protein -
HPY14_RS15395 387247..387429 + 183 WP_001933122.1 DUF645 family protein -
HPY14_RS15400 387638..388195 + 558 WP_095488179.1 3'-5' exonuclease -
HPY14_RS15405 388192..388302 + 111 Protein_393 DUF3265 domain-containing protein -
HPY14_RS15410 388310..388609 - 300 WP_000802131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY14_RS15415 388606..388848 - 243 WP_002044787.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HPY14_RS15420 388896..389027 + 132 WP_080483479.1 DUF3265 domain-containing protein -
HPY14_RS15425 389056..389553 + 498 WP_094392957.1 DUF2867 domain-containing protein -
HPY14_RS15430 389858..390028 + 171 WP_094392956.1 DUF645 family protein -
HPY14_RS15435 390244..390639 + 396 WP_094392955.1 cell envelope integrity protein TolA -
HPY14_RS15440 390922..391113 + 192 WP_094392953.1 DUF3709 domain-containing protein -
HPY14_RS15445 391464..391817 + 354 WP_172626102.1 nuclear transport factor 2 family protein -
HPY14_RS15450 392107..392520 + 414 WP_061036318.1 hypothetical protein -
HPY14_RS15455 392810..392992 + 183 WP_094392952.1 DUF645 family protein -
HPY14_RS15460 393244..393798 + 555 WP_108244021.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 307775..455729 147954
- inside Integron - - 308939..456912 147973


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11607.26 Da        Isoelectric Point: 9.9232

>T157891 WP_000802131.1 NZ_CP053799:c388609-388310 [Vibrio cholerae]
MKPFNLTTAAKTDLRDIALFTQRRWGKEQRNIYLKQFDDSFWLLAENPDIGKSCDEIRDGYRKFPQGSHVIFYQQTGSQQ
IRVVRILHKSMDVNPIFGA

Download         Length: 300 bp

>T157891 NZ_CP069501:2375401-2375679 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCAGATATCGATATGCCCGGTTACCGATTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGGATAACGTTCGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8979.81 Da        Isoelectric Point: 4.1677

>AT157891 WP_002044787.1 NZ_CP053799:c388848-388606 [Vibrio cholerae]
MAKNTSITLGEHFDGFITNQIQSGRYGSASEVIRSALRLLENQETKLQTLRQLLVEGEQSGDADYDLDSFINELDSETNR

Download         Length: 243 bp

>AT157891 NZ_CP069501:2375679-2375963 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCTATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGCCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N8UHD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0JMN6

References