Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 377620..378167 Replicon chromosome
Accession NZ_CP053799
Organism Vibrio cholerae strain SL5Y

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HPY14_RS15315 Protein ID WP_094393067.1
Coordinates 377865..378167 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag HPY14_RS15310 Protein ID WP_000861987.1
Coordinates 377620..377877 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY14_RS15270 373156..373665 + 510 WP_000405988.1 GNAT family N-acetyltransferase -
HPY14_RS15275 373800..374117 - 318 WP_059261326.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY14_RS15280 374136..374378 - 243 WP_000288450.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY14_RS15285 374639..375379 + 741 WP_162298990.1 PhzF family phenazine biosynthesis protein -
HPY14_RS15290 375674..375856 + 183 WP_094393107.1 DUF645 family protein -
HPY14_RS15295 376175..376453 + 279 WP_005526581.1 DUF3601 domain-containing protein -
HPY14_RS15300 376522..376605 + 84 WP_080478874.1 acetyltransferase -
HPY14_RS15305 376618..376977 + 360 WP_094393079.1 VOC family protein -
HPY14_RS15310 377620..377877 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY14_RS15315 377865..378167 + 303 WP_094393067.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY14_RS15320 378325..378873 + 549 WP_094393068.1 hypothetical protein -
HPY14_RS15325 378992..379363 + 372 WP_162298937.1 DUF4144 domain-containing protein -
HPY14_RS15330 379638..379874 + 237 WP_161783514.1 DUF3709 domain-containing protein -
HPY14_RS15335 380311..380397 + 87 WP_162843094.1 DUF645 family protein -
HPY14_RS15340 380397..380489 + 93 Protein_380 DUF645 family protein -
HPY14_RS15345 380639..381124 + 486 WP_175234067.1 GNAT family N-acetyltransferase -
HPY14_RS15350 381297..381887 + 591 WP_094392960.1 TIR domain-containing protein -
HPY14_RS15355 382070..382954 + 885 WP_103155538.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 307775..455729 147954
- inside Integron - - 308939..456912 147973


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 11793.73 Da        Isoelectric Point: 5.1972

>T157890 WP_094393067.1 NZ_CP053799:377865-378167 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAARQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T157890 NZ_CP069501:2014882-2014984 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT157890 WP_000861987.1 NZ_CP053799:377620-377877 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT157890 NZ_CP069501:c2015022-2014751 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References