Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-Phd |
Location | 377620..378167 | Replicon | chromosome |
Accession | NZ_CP053799 | ||
Organism | Vibrio cholerae strain SL5Y |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | HPY14_RS15315 | Protein ID | WP_094393067.1 |
Coordinates | 377865..378167 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q9KM93 |
Locus tag | HPY14_RS15310 | Protein ID | WP_000861987.1 |
Coordinates | 377620..377877 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HPY14_RS15270 | 373156..373665 | + | 510 | WP_000405988.1 | GNAT family N-acetyltransferase | - |
HPY14_RS15275 | 373800..374117 | - | 318 | WP_059261326.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
HPY14_RS15280 | 374136..374378 | - | 243 | WP_000288450.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
HPY14_RS15285 | 374639..375379 | + | 741 | WP_162298990.1 | PhzF family phenazine biosynthesis protein | - |
HPY14_RS15290 | 375674..375856 | + | 183 | WP_094393107.1 | DUF645 family protein | - |
HPY14_RS15295 | 376175..376453 | + | 279 | WP_005526581.1 | DUF3601 domain-containing protein | - |
HPY14_RS15300 | 376522..376605 | + | 84 | WP_080478874.1 | acetyltransferase | - |
HPY14_RS15305 | 376618..376977 | + | 360 | WP_094393079.1 | VOC family protein | - |
HPY14_RS15310 | 377620..377877 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
HPY14_RS15315 | 377865..378167 | + | 303 | WP_094393067.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HPY14_RS15320 | 378325..378873 | + | 549 | WP_094393068.1 | hypothetical protein | - |
HPY14_RS15325 | 378992..379363 | + | 372 | WP_162298937.1 | DUF4144 domain-containing protein | - |
HPY14_RS15330 | 379638..379874 | + | 237 | WP_161783514.1 | DUF3709 domain-containing protein | - |
HPY14_RS15335 | 380311..380397 | + | 87 | WP_162843094.1 | DUF645 family protein | - |
HPY14_RS15340 | 380397..380489 | + | 93 | Protein_380 | DUF645 family protein | - |
HPY14_RS15345 | 380639..381124 | + | 486 | WP_175234067.1 | GNAT family N-acetyltransferase | - |
HPY14_RS15350 | 381297..381887 | + | 591 | WP_094392960.1 | TIR domain-containing protein | - |
HPY14_RS15355 | 382070..382954 | + | 885 | WP_103155538.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 307775..455729 | 147954 | |
- | inside | Integron | - | - | 308939..456912 | 147973 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11793.73 Da Isoelectric Point: 5.1972
>T157890 WP_094393067.1 NZ_CP053799:377865-378167 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAARQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTEPALSDLNDIAEYIALENVVAARQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T157890 NZ_CP069501:2014882-2014984 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT157890 WP_000861987.1 NZ_CP053799:377620-377877 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT157890 NZ_CP069501:c2015022-2014751 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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