Detailed information of TA system TA157889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 373800..374378
• Replicon: chromosome
• Accession: NZ_CP053799
• Organism: Vibrio cholerae strain SL5Y

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HPY14_RS15275
• Protein ID: WP_059261326.1
• Coordinates: 373800..374117 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: HPY14_RS15280
• Protein ID: WP_000288450.1
• Coordinates: 374136..374378 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY14_RS15250	369304..370263	-	960	WP_094393086.1	IS30 family transposase	-
HPY14_RS15255	370538..371164	+	627	WP_095488387.1	hypothetical protein	-
HPY14_RS15260	371202..372161	-	960	WP_094393086.1	IS30 family transposase	-
HPY14_RS15265	372398..372997	+	600	WP_095464298.1	hypothetical protein	-
HPY14_RS15270	373156..373665	+	510	WP_000405988.1	GNAT family N-acetyltransferase	-
HPY14_RS15275	373800..374117	-	318	WP_059261326.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY14_RS15280	374136..374378	-	243	WP_000288450.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY14_RS15285	374639..375379	+	741	WP_162298990.1	PhzF family phenazine biosynthesis protein	-
HPY14_RS15290	375674..375856	+	183	WP_094393107.1	DUF645 family protein	-
HPY14_RS15295	376175..376453	+	279	WP_005526581.1	DUF3601 domain-containing protein	-
HPY14_RS15300	376522..376605	+	84	WP_080478874.1	acetyltransferase	-
HPY14_RS15305	376618..376977	+	360	WP_094393079.1	VOC family protein	-
HPY14_RS15310	377620..377877	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY14_RS15315	377865..378167	+	303	WP_094393067.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY14_RS15320	378325..378873	+	549	WP_094393068.1	hypothetical protein	-
HPY14_RS15325	378992..379363	+	372	WP_162298937.1	DUF4144 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	307775..455729	147954
	-	inside	Integron	-	-	308939..456912	147973

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12194.02 Da
• Isoelectric Point: 9.5547

>T157889 WP_059261326.1 NZ_CP053799:c374117-373800 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIRNYTIENFAQAQWLKYKSTLLSGFQTLADNPELGKSCEDIYKNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLTQSRFVS

Nucleotide

• Length: 318 bp

>T157889 NZ_CP069501:c1564885-1564499 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAAGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAGGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8987.28 Da
• Isoelectric Point: 5.0491

>AT157889 WP_000288450.1 NZ_CP053799:c374378-374136 [Vibrio cholerae]
MYTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT157889 NZ_CP069501:c1564509-1564180 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA